OBJECTIVE: Human leukocyte antigen DQ (HLA-DQ) genetic factors and islet autoantibodies are strongly associated with type 1 diabetes (T1D) and are currently used to predict T1D. This study examined whether islet autoantibodies in the cord blood of newborns to nondiabetic mothers were associated with the (T1D) high-risk genotype HLA-DQ2/8, gestational infections or both. STUDY DESIGN: Cord blood samples were taken from 33 683 newborns and used for HLA typing and analyses of islet autoantibodies. Parents completed questionnaires when the child was 2 months of age. RESULT: The prevalence of newborn islet autoantibodies consistently varied with season over 4 years (P<0.0001); lowest in first quarter (1.2%) and highest in third (2.4%). Cord blood islet autoantibodies were associated with HLA-DQ2/8 in the second (OR, 2.30; P=0.02), third (OR, 2.12; P=0.008) and fourth quarters (OR, 2.49; P=0.007), but not in the first (OR, 1.13). Reported gastroenteritis was additionally associated with islet autoantibodies in the third quarter (OR, 1.80, P=0.04). CONCLUSION: An association between HLA and islet autoimmunity may depend on environmental exposure during pregnancy. Follow-up of mothers and children will determine risk of T1D.
OBJECTIVE:Human leukocyte antigen DQ (HLA-DQ) genetic factors and islet autoantibodies are strongly associated with type 1 diabetes (T1D) and are currently used to predict T1D. This study examined whether islet autoantibodies in the cord blood of newborns to nondiabetic mothers were associated with the (T1D) high-risk genotype HLA-DQ2/8, gestational infections or both. STUDY DESIGN: Cord blood samples were taken from 33 683 newborns and used for HLA typing and analyses of islet autoantibodies. Parents completed questionnaires when the child was 2 months of age. RESULT: The prevalence of newborn islet autoantibodies consistently varied with season over 4 years (P<0.0001); lowest in first quarter (1.2%) and highest in third (2.4%). Cord blood islet autoantibodies were associated with HLA-DQ2/8 in the second (OR, 2.30; P=0.02), third (OR, 2.12; P=0.008) and fourth quarters (OR, 2.49; P=0.007), but not in the first (OR, 1.13). Reported gastroenteritis was additionally associated with islet autoantibodies in the third quarter (OR, 1.80, P=0.04). CONCLUSION: An association between HLA and islet autoimmunity may depend on environmental exposure during pregnancy. Follow-up of mothers and children will determine risk of T1D.
Authors: Jeffrey P Krischer; Kristian F Lynch; Desmond A Schatz; Jorma Ilonen; Åke Lernmark; William A Hagopian; Marian J Rewers; Jin-Xiong She; Olli G Simell; Jorma Toppari; Anette-G Ziegler; Beena Akolkar; Ezio Bonifacio Journal: Diabetologia Date: 2015-02-10 Impact factor: 10.122
Authors: A Papadopoulou; K F Lynch; N Shaat; R Håkansson; S A Ivarsson; K Berntorp; C D Agardh; Å Lernmark Journal: Diabet Med Date: 2011-09 Impact factor: 4.359
Authors: A Papadopoulou; K F Lynch; N Shaat; A Nilsson; B Lernmark; K Berntorp; S-A Ivarsson; C-D Agardh; A Lernmark Journal: Diabetologia Date: 2009-04-04 Impact factor: 10.122
Authors: Markus Lundgren; Åsa Sahlin; Camilla Svensson; Annelie Carlsson; Elisabeth Cedervall; Björn Jönsson; Ida Jönsson; Karin Larsson; Åke Lernmark; Jan Neiderud; Tore Vigård; Helena Elding Larsson Journal: Pediatr Diabetes Date: 2014-05-13 Impact factor: 4.866
Authors: B Jonsdottir; C Andersson; A Carlsson; A Delli; G Forsander; J Ludvigsson; C Marcus; U Samuelsson; E Ortqvist; A Lernmark; S-A Ivarsson; H Elding Larsson Journal: Diabetologia Date: 2013-05-12 Impact factor: 10.122
Authors: Kristian F Lynch; Hye-Seung Lee; Carina Törn; Kendra Vehik; Jeffrey P Krischer; Helena Elding Larsson; Michael J Haller; William A Hagopian; Marian J Rewers; Jin-Xiong She; Olli G Simell; Jorma Toppari; Anette-G Ziegler; Beena Akolkar; Heikki Hyöty; Ezio Bonifacio; Åke Lernmark Journal: J Autoimmun Date: 2017-09-21 Impact factor: 14.511