Eric Jouvent1, Anand Viswanathan, Hugues Chabriat. 1. Department of Neurology, Hôpital Lariboisiere, Assistance Pulique-Hôpitaux de Paris and Université Paris VII, Paris, France.
Abstract
BACKGROUND AND PURPOSE: Various neurological disorders have been shown to accelerate the natural course of brain volume loss during normal aging. Recent data suggest that brain atrophy is prominent in various cerebrovascular disorders. Studies of the effects of different cerebrovascular magnetic resonance imaging (MRI) markers and of the effects of various vascular risk factors on the cerebral volume have been analyzed. SUMMARY OF REVIEW: A significant association between white matter hyperintensities and cerebral atrophy has been reported in population-based studies. However, these results remain controversial since they have not yet been confirmed in longitudinal studies. The association between lacunar infarctions and cerebral atrophy was only rarely investigated. This was also true for cerebral microbleeds. In contrast, different data suggest that brain atrophy is associated with elevated blood pressure values or hyperglycemia, independent of the occurrence of extension of visible MRI markers of vascular lesions. CONCLUSION: Additional studies are needed to determine the exact impact of vascular risk factors or other cerebrovascular lesions seen on MRI on the course of cerebral atrophy. In the future, new MRI markers may help to better delineate the role of focal tissue lesions from that of diffuse effects of vascular risk factors on the cerebral atrophy process.
BACKGROUND AND PURPOSE: Various neurological disorders have been shown to accelerate the natural course of brain volume loss during normal aging. Recent data suggest that brain atrophy is prominent in various cerebrovascular disorders. Studies of the effects of different cerebrovascular magnetic resonance imaging (MRI) markers and of the effects of various vascular risk factors on the cerebral volume have been analyzed. SUMMARY OF REVIEW: A significant association between white matter hyperintensities and cerebral atrophy has been reported in population-based studies. However, these results remain controversial since they have not yet been confirmed in longitudinal studies. The association between lacunar infarctions and cerebral atrophy was only rarely investigated. This was also true for cerebral microbleeds. In contrast, different data suggest that brain atrophy is associated with elevated blood pressure values or hyperglycemia, independent of the occurrence of extension of visible MRI markers of vascular lesions. CONCLUSION: Additional studies are needed to determine the exact impact of vascular risk factors or other cerebrovascular lesions seen on MRI on the course of cerebral atrophy. In the future, new MRI markers may help to better delineate the role of focal tissue lesions from that of diffuse effects of vascular risk factors on the cerebral atrophy process.
Authors: François De Guio; Marco Duering; Franz Fazekas; Frank-Erik De Leeuw; Steven M Greenberg; Leonardo Pantoni; Agnès Aghetti; Eric E Smith; Joanna Wardlaw; Eric Jouvent Journal: J Cereb Blood Flow Metab Date: 2019-11-20 Impact factor: 6.200
Authors: François De Guio; Eric Jouvent; Geert Jan Biessels; Sandra E Black; Carol Brayne; Christopher Chen; Charlotte Cordonnier; Frank-Eric De Leeuw; Martin Dichgans; Fergus Doubal; Marco Duering; Carole Dufouil; Emrah Duzel; Franz Fazekas; Vladimir Hachinski; M Arfan Ikram; Jennifer Linn; Paul M Matthews; Bernard Mazoyer; Vincent Mok; Bo Norrving; John T O'Brien; Leonardo Pantoni; Stefan Ropele; Perminder Sachdev; Reinhold Schmidt; Sudha Seshadri; Eric E Smith; Luciano A Sposato; Blossom Stephan; Richard H Swartz; Christophe Tzourio; Mark van Buchem; Aad van der Lugt; Robert van Oostenbrugge; Meike W Vernooij; Anand Viswanathan; David Werring; Frank Wollenweber; Joanna M Wardlaw; Hugues Chabriat Journal: J Cereb Blood Flow Metab Date: 2016-05-11 Impact factor: 6.200
Authors: Andre Monteiro; Muhammad Waqas; Hamid H Rai; Ammad A Baig; Rimal H Dossani; Justin M Cappuzzo; Elad I Levy; Adnan H Siddiqui Journal: Br J Radiol Date: 2022-01-31 Impact factor: 3.629
Authors: Yael D Reijmer; Panagiotis Fotiadis; Giovanni Piantoni; Gregoire Boulouis; Kathleen E Kelly; Mahmut E Gurol; Alexander Leemans; Michael J O'Sullivan; Steven M Greenberg; Anand Viswanathan Journal: Hum Brain Mapp Date: 2016-03-23 Impact factor: 5.038