Literature DB >> 1934342

Myocyte mitotic division in the aging mammalian rat heart.

P Anversa1, D Fitzpatrick, S Argani, J M Capasso.   

Abstract

To determine whether myocyte mitotic division occurs in the adult mammalian heart and whether this cellular process is affected by aging, we measured the percentage of myocyte nuclei showing metaphase chromosomes in myocytes isolated from the left and right ventricles of rats at 8-12, 19-24, and 28-32 months after birth. Metaphase chromosomes were found at all ages in both ventricles. However, from 8-12 to 28-32 months, the fraction of nuclei exhibiting metaphase chromosomes increased 6.3-fold and 2.3-fold in the left and right ventricles, respectively. Thus, myocyte cellular hyperplasia is present in the adult and aging myocardium as a compensatory mechanism to regenerate tissue mass and recover function, which are lost with the progression of life and senescence.

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Year:  1991        PMID： 1934342     DOI： 10.1161/01.res.69.4.1159

Source DB:  PubMed          Journal:  Circ Res        ISSN： 0009-7330            Impact factor:   17.367


  15 in total

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7.  Insights from animal models of myocardial infarction: do ACE inhibitors limit the structural response?

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8.  Overexpression of insulin-like growth factor-1 in the heart is coupled with myocyte proliferation in transgenic mice.

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Review 9.  Is the senescent heart overloaded and already failing?

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10.  Metabolic dysfunction consistent with premature aging results from deletion of Pim kinases.

Authors:  Shabana Din; Mathias H Konstandin; Bevan Johnson; Jacqueline Emathinger; Mirko Völkers; Haruhiro Toko; Brett Collins; Lucy Ormachea; Kaitlen Samse; Dieter A Kubli; Andrea De La Torre; Andrew S Kraft; Asa B Gustafsson; Daniel P Kelly; Mark A Sussman
Journal:  Circ Res       Date:  2014-06-10       Impact factor: 17.367
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