Viroj Wiwanitkit1. 1. Wiwanitkit House, Bangkhae, Bangkok, Thailand.
Abstract
BACKGROUND: KCNQ channels play important roles in controlling membrane excitability. A reduction in KCNQ channel activity due to genetic mutation is responsible for various human diseases, including arrhythmia. METHODS: A combined bioinformatics analysis was performed to study the positions that are at risk for mutation within the amino acid sequence of KCNQ. A new bioinformatics tool, namely GlobPlot, was used. RESULTS: According to the present study, the positions that are resistant to mutation are predicted. CONCLUSION: Several mutation-prone positions within the KCNQ sequence are reported.
BACKGROUND:KCNQ channels play important roles in controlling membrane excitability. A reduction in KCNQ channel activity due to genetic mutation is responsible for various human diseases, including arrhythmia. METHODS: A combined bioinformatics analysis was performed to study the positions that are at risk for mutation within the amino acid sequence of KCNQ. A new bioinformatics tool, namely GlobPlot, was used. RESULTS: According to the present study, the positions that are resistant to mutation are predicted. CONCLUSION: Several mutation-prone positions within the KCNQ sequence are reported.
Authors: Elisabeth Gasteiger; Alexandre Gattiker; Christine Hoogland; Ivan Ivanyi; Ron D Appel; Amos Bairoch Journal: Nucleic Acids Res Date: 2003-07-01 Impact factor: 16.971
Authors: Karen Ocorr; Nick L Reeves; Robert J Wessells; Martin Fink; H-S Vincent Chen; Takeshi Akasaka; Soichiro Yasuda; Joseph M Metzger; Wayne Giles; James W Posakony; Rolf Bodmer Journal: Proc Natl Acad Sci U S A Date: 2007-02-28 Impact factor: 11.205