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Literature DB >> 19340594

Multi-faceted role of HSP40 in cancer.

Aparna Mitra¹, Lalita A Shevde, Rajeev S Samant.

Abstract

HSP40 (DNAJ) is an understudied family of co-chaperones. The human genome codes for over 41 members of HSP40 family that reside at distinct intracellular locations. Despite their large numbers, little is known about their physiologic roles. Recent research has revealed involvement of some of the DNAJ family members in various types of cancers. In this article we summarize the information about the involvement of human DNAJ family members in various aspects of cancer biology. Furthermore we discuss the potential role of the J domain of DNAJ proteins in cancer biology.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2009 PMID： 19340594 DOI： 10.1007/s10585-009-9255-x

Source DB: PubMed Journal: Clin Exp Metastasis ISSN： 0262-0898 Impact factor: 5.150

102 in total

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Journal: J Biol Chem Date: 2006-03-10 Impact factor: 5.157

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7. Phase II and pharmacodynamic study of the farnesyltransferase inhibitor R115777 as initial therapy in patients with metastatic pancreatic adenocarcinoma.

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Journal: J Clin Oncol Date: 2003-04-01 Impact factor: 44.544

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Journal: J Virol Date: 2003-10 Impact factor: 5.103

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10. Large isoform of MRJ (DNAJB6) reduces malignant activity of breast cancer.

Authors: Aparna Mitra; Rebecca A Fillmore; Brandon J Metge; Mathur Rajesh; Yaguang Xi; Judy King; Jingfang Ju; Lewis Pannell; Lalita A Shevde; Rajeev S Samant
Journal: Breast Cancer Res Date: 2008-03-07 Impact factor: 6.466

41 in total

1. DNAJB6 chaperones PP2A mediated dephosphorylation of GSK3β to downregulate β-catenin transcription target, osteopontin.

Authors: A Mitra; M E Menezes; L K Pannell; M S Mulekar; R E Honkanen; L A Shevde; R S Samant
Journal: Oncogene Date: 2012-01-23 Impact factor: 9.867

2. Cellular stress stimulates nuclear localization signal (NLS) independent nuclear transport of MRJ.

Authors: Joel F Andrews; Landon J Sykora; Tiasha Barik Letostak; Mitchell E Menezes; Aparna Mitra; Sailen Barik; Lalita A Shevde; Rajeev S Samant
Journal: Exp Cell Res Date: 2012-04-03 Impact factor: 3.905

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Authors: Chad Smith; Santosh R D'Mello
Journal: Mol Neurobiol Date: 2015-10-17 Impact factor: 5.590

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Journal: J Leukoc Biol Date: 2013-08-29 Impact factor: 4.962

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Authors: Ohad Iosefson; Shelly Sharon; Pierre Goloubinoff; Abdussalam Azem
Journal: Cell Stress Chaperones Date: 2011-08-03 Impact factor: 3.667

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Authors: Herman van der Putten; Gregor P Lotz
Journal: Neurotherapeutics Date: 2013-07 Impact factor: 7.620