Literature DB >> 19339972

Structural basis for assembly and disassembly of the CRM1 nuclear export complex.

Xiuhua Dong1, Anindita Biswas, Yuh Min Chook.   

Abstract

CRM1 (or exportin 1, Xpo1) transports proteins out of the cell nucleus through the nuclear pore complex. In the cytoplasm, GTP hydrolysis and consequent dissociation of Ran from CRM1 releases low-affinity substrates, while additional factors facilitate release of high-affinity substrates. Here we provide a model for human CRM1 export complex assembly and disassembly through structural and biochemical analyses of CRM1 bound to the substrate snurportin 1 (SNUPN, also called snuportin 1).

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Year:  2009        PMID： 19339972      PMCID： PMC3437629          DOI： 10.1038/nsmb.1586

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  14 in total

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Authors:  D Görlich; U Kutay
Journal:  Annu Rev Cell Dev Biol       Date:  1999       Impact factor: 13.827

2.  Exportin 1 (Crm1p) is an essential nuclear export factor.

Authors:  K Stade; C S Ford; C Guthrie; K Weis
Journal:  Cell       Date:  1997-09-19       Impact factor: 41.582

3.  Evidence for a role of CRM1 in signal-mediated nuclear protein export.

Authors:  B Ossareh-Nazari; F Bachelerie; C Dargemont
Journal:  Science       Date:  1997-10-03       Impact factor: 47.728

4.  CRM1 is an export receptor for leucine-rich nuclear export signals.

Authors:  M Fornerod; M Ohno; M Yoshida; I W Mattaj
Journal:  Cell       Date:  1997-09-19       Impact factor: 41.582

5.  CRM1 is responsible for intracellular transport mediated by the nuclear export signal.

Authors:  M Fukuda; S Asano; T Nakamura; M Adachi; M Yoshida; M Yanagida; E Nishida
Journal:  Nature       Date:  1997-11-20       Impact factor: 49.962

6.  Architecture of CRM1/Exportin1 suggests how cooperativity is achieved during formation of a nuclear export complex.

Authors:  Carlo Petosa; Guy Schoehn; Peter Askjaer; Ulrike Bauer; Martine Moulin; Ulrich Steuerwald; Montserrat Soler-López; Florence Baudin; Iain W Mattaj; Christoph W Müller
Journal:  Mol Cell       Date:  2004-12-03       Impact factor: 17.970

7.  Supraphysiological nuclear export signals bind CRM1 independently of RanGTP and arrest at Nup358.

Authors:  Dieuwke Engelsma; Rafael Bernad; Jero Calafat; Maarten Fornerod
Journal:  EMBO J       Date:  2004-08-26       Impact factor: 11.598

8.  The specificity of the CRM1-Rev nuclear export signal interaction is mediated by RanGTP.

Authors:  P Askjaer; T H Jensen; J Nilsson; L Englmeier; J Kjems
Journal:  J Biol Chem       Date:  1998-12-11       Impact factor: 5.157

9.  Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structure.

Authors:  J Huber; U Cronshagen; M Kadokura; C Marshallsay; T Wada; M Sekine; R Lührmann
Journal:  EMBO J       Date:  1998-07-15       Impact factor: 11.598

10.  CRM1-mediated recycling of snurportin 1 to the cytoplasm.

Authors:  E Paraskeva; E Izaurralde; F R Bischoff; J Huber; U Kutay; E Hartmann; R Lührmann; D Görlich
Journal:  J Cell Biol       Date:  1999-04-19       Impact factor: 10.539
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  46 in total

1.  An allosteric mechanism to displace nuclear export cargo from CRM1 and RanGTP by RanBP1.

Authors:  Masako Koyama; Yoshiyuki Matsuura
Journal:  EMBO J       Date:  2010-05-18       Impact factor: 11.598

2.  Nuclear transport comes full circle.

Authors:  Erik W Debler; Günter Blobel; André Hoelz
Journal:  Nat Struct Mol Biol       Date:  2009-05       Impact factor: 15.369

3.  Structures of the tRNA export factor in the nuclear and cytosolic states.

Authors:  Atlanta G Cook; Noemi Fukuhara; Martin Jinek; Elena Conti
Journal:  Nature       Date:  2009-09-03       Impact factor: 49.962

4.  Nuclear-Cytoplasmic Transport Is a Therapeutic Target in Myelofibrosis.

Authors:  Dongqing Yan; Anthony D Pomicter; Srinivas Tantravahi; Clinton C Mason; Anna V Senina; Jonathan M Ahmann; Qiang Wang; Hein Than; Ami B Patel; William L Heaton; Anna M Eiring; Phillip M Clair; Kevin C Gantz; Hannah M Redwine; Sabina I Swierczek; Brayden J Halverson; Erkan Baloglu; Sharon Shacham; Jamshid S Khorashad; Todd W Kelley; Mohamed E Salama; Rodney R Miles; Kenneth M Boucher; Josef T Prchal; Thomas O'Hare; Michael W Deininger
Journal:  Clin Cancer Res       Date:  2018-12-18       Impact factor: 12.531

5.  Structural basis for the nuclear export activity of Importin13.

Authors:  Marlene Grünwald; Daniela Lazzaretti; Fulvia Bono
Journal:  EMBO J       Date:  2013-02-22       Impact factor: 11.598

Review 6.  Expression, function, and targeting of the nuclear exporter chromosome region maintenance 1 (CRM1) protein.

Authors:  Jo Ishizawa; Kensuke Kojima; Numsen Hail; Yoko Tabe; Michael Andreeff
Journal:  Pharmacol Ther       Date:  2015-06-03       Impact factor: 12.310

Review 7.  The coming-of-age of nucleocytoplasmic transport in motor neuron disease and neurodegeneration.

Authors:  Paulo A Ferreira
Journal:  Cell Mol Life Sci       Date:  2019-02-11       Impact factor: 9.261

8.  Structural basis for cooperativity of CRM1 export complex formation.

Authors:  Thomas Monecke; David Haselbach; Béla Voß; Andreas Russek; Piotr Neumann; Emma Thomson; Ed Hurt; Ulrich Zachariae; Holger Stark; Helmut Grubmüller; Achim Dickmanns; Ralf Ficner
Journal:  Proc Natl Acad Sci U S A       Date:  2012-12-31       Impact factor: 11.205

Review 9.  Atomic basis of CRM1-cargo recognition, release and inhibition.

Authors:  Ho Yee Joyce Fung; Yuh Min Chook
Journal:  Semin Cancer Biol       Date:  2014-03-12       Impact factor: 15.707

Review 10.  Inhibition of CRM1-dependent nuclear export sensitizes malignant cells to cytotoxic and targeted agents.

Authors:  Joel G Turner; Jana Dawson; Christopher L Cubitt; Rachid Baz; Daniel M Sullivan
Journal:  Semin Cancer Biol       Date:  2014-03-12       Impact factor: 15.707
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