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Literature DB >> 19339181

Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3).

Scott D Kuduk¹, Christina N Di Marco, Ronald K Chang, Robert M Dipardo, Sean P Cook, Matthew J Cato, Aneta Jovanovska, Mark O Urban, Michael Leitl, Robert H Spencer, Stefanie A Kane, Mark T Bilodeau, George D Hartman, Mark G Bock.

Abstract

A series of amiloride derivatives modified at the 5-position of the pyrazine ring were evaluated as inhibitors of acid-sensing ion channel-3 (ASIC3), a novel target for the treatment of chronic pain.

Entities: Chemical Disease Gene

Mesh：

Substances：

Year: 2009 PMID： 19339181 DOI： 10.1016/j.bmcl.2009.03.029

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

17 in total

1. Synthesis, structure-activity relationship, and pharmacological profile of analogs of the ASIC-3 inhibitor A-317567.

Authors: Scott D Kuduk; Christina N Di Marco; Vera Bodmer-Narkevitch; Sean P Cook; Matthew J Cato; Aneta Jovanovska; Mark O Urban; Michael Leitl; Nova Sain; Annie Liang; Robert H Spencer; Stefanie A Kane; George D Hartman; Mark T Bilodeau
Journal: ACS Chem Neurosci Date: 2009-10-06 Impact factor: 4.418

2. Diarylamidines: high potency inhibitors of acid-sensing ion channels.

Authors: Xuanmao Chen; Liyan Qiu; Minghua Li; Stefan Dürrnagel; Beverley A Orser; Zhi-Gang Xiong; John F MacDonald
Journal: Neuropharmacology Date: 2010-01-28 Impact factor: 5.250

Review 3. ENaCs and ASICs as therapeutic targets.

Authors: Yawar J Qadri; Arun K Rooj; Catherine M Fuller
Journal: Am J Physiol Cell Physiol Date: 2012-01-25 Impact factor: 4.249

Review 4. The function and regulation of acid-sensing ion channels (ASICs) and the epithelial Na(+) channel (ENaC): IUPHAR Review 19.

Authors: Emilie Boscardin; Omar Alijevic; Edith Hummler; Simona Frateschi; Stephan Kellenberger
Journal: Br J Pharmacol Date: 2016-08-10 Impact factor: 8.739

Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3).

1. Synthesis, structure-activity relationship, and pharmacological profile of analogs of the ASIC-3 inhibitor A-317567.

2. Diarylamidines: high potency inhibitors of acid-sensing ion channels.

Review 3. ENaCs and ASICs as therapeutic targets.

Review 4. The function and regulation of acid-sensing ion channels (ASICs) and the epithelial Na(+) channel (ENaC): IUPHAR Review 19.

5. Reversal of acid-induced and inflammatory pain by the selective ASIC3 inhibitor, APETx2.

6. Femoral artery occlusion increases expression of ASIC3 in dorsal root ganglion neurons.

Review 7. Acid-sensing ion channels 3: a potential therapeutic target for pain treatment in arthritis.

8. 5-(N, N-Hexamethylene) amiloride is a GABA-A ρ1 receptor positive allosteric modulator.

Review 9. Acid-sensing ion channels: A new target for pain and CNS diseases.

10. Amiloride docking to acid-sensing ion channel-1.