Literature DB >> 22778804

Synthesis, structure-activity relationship, and pharmacological profile of analogs of the ASIC-3 inhibitor A-317567.

Scott D Kuduk1, Christina N Di Marco, Vera Bodmer-Narkevitch, Sean P Cook, Matthew J Cato, Aneta Jovanovska, Mark O Urban, Michael Leitl, Nova Sain, Annie Liang, Robert H Spencer, Stefanie A Kane, George D Hartman, Mark T Bilodeau.   

Abstract

The synthesis, structure-activity relationship (SAR), and pharmacological evaluation of analogs of the acid-sensing ion channel (ASIC) inhibitor A-317567 are reported. It was found that the compound with an acetylenic linkage was the most potent ASIC-3 channel blocker. This compound reversed mechanical hypersensitivity in the rat iodoacetate model of osteoarthritis pain, although sedation was noted. Sedation was also observed in ASIC-3 knockout mice, questioning whether sedation and antinociception are mediated via a non-ASIC-3 specific mechanism.

Entities:  

Keywords:  ASIC-3; Pain; acid-sensing; degenerin; ion channel

Mesh：

Substances：

Year:  2009        PMID： 22778804      PMCID： PMC3368628          DOI： 10.1021/cn9000186

Source DB:  PubMed          Journal:  ACS Chem Neurosci        ISSN： 1948-7193            Impact factor:   4.418


  28 in total

1.  Antinociception produced by systemic, spinal and supraspinal administration of amiloride in mice.

Authors:  J Ferreira; A R Santos; J B Calixto
Journal:  Life Sci       Date:  1999       Impact factor: 5.037

2.  Proinflammatory mediators, stimulators of sensory neuron excitability via the expression of acid-sensing ion channels.

Authors:  Julien Mamet; Anne Baron; Michel Lazdunski; Nicolas Voilley
Journal:  J Neurosci       Date:  2002-12-15       Impact factor: 6.167

3.  Selective NMDA NR2B antagonists induce antinociception without motor dysfunction: correlation with restricted localisation of NR2B subunit in dorsal horn.

Authors:  S Boyce; A Wyatt; J K Webb; R O'Donnell; G Mason; M Rigby; D Sirinathsinghji; R G Hill; N M Rupniak
Journal:  Neuropharmacology       Date:  1999-05       Impact factor: 5.250

4.  Acid-induced pain and its modulation in humans.

Authors:  Nicholas G Jones; Rebeccah Slater; Herve Cadiou; Peter McNaughton; Stephen B McMahon
Journal:  J Neurosci       Date:  2004-12-01       Impact factor: 6.167

5.  Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1.

Authors:  Kathleen A Sluka; Margaret P Price; Nicole M Breese; Cheryl L Stucky; John A Wemmie; Michael J Welsh
Journal:  Pain       Date:  2003-12       Impact factor: 6.961

6.  Unilateral inflammation of the hindpaw in rats as a model of prolonged noxious stimulation: alterations in behavior and nociceptive thresholds.

Authors:  C Stein; M J Millan; A Herz
Journal:  Pharmacol Biochem Behav       Date:  1988-10       Impact factor: 3.533

7.  Molecular cloning and regional distribution of a human proton receptor subunit with biphasic functional properties.

Authors:  K Babinski; K T Lê; P Séguéla
Journal:  J Neurochem       Date:  1999-01       Impact factor: 5.372

8.  Quantitative assessment of tactile allodynia in the rat paw.

Authors:  S R Chaplan; F W Bach; J W Pogrel; J M Chung; T L Yaksh
Journal:  J Neurosci Methods       Date:  1994-07       Impact factor: 2.390

9.  Acid-sensing ion channel 2 (ASIC2) modulates ASIC1 H+-activated currents in hippocampal neurons.

Authors:  Candice C Askwith; John A Wemmie; Margaret P Price; Tania Rokhlina; Michael J Welsh
Journal:  J Biol Chem       Date:  2004-02-11       Impact factor: 5.157

10.  Amiloride-blockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors.

Authors:  Shinya Ugawa; Takashi Ueda; Yusuke Ishida; Makoto Nishigaki; Yasuhiro Shibata; Shoichi Shimada
Journal:  J Clin Invest       Date:  2002-10       Impact factor: 14.808
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  7 in total

Review 1.  The function and regulation of acid-sensing ion channels (ASICs) and the epithelial Na(+) channel (ENaC): IUPHAR Review 19.

Authors:  Emilie Boscardin; Omar Alijevic; Edith Hummler; Simona Frateschi; Stephan Kellenberger
Journal:  Br J Pharmacol       Date:  2016-08-10       Impact factor: 8.739

2.  Subtype-selective inhibition of acid-sensing ion channel 3 by a natural flavonoid.

Authors:  Xiao-Gang Yan; Wei-Guang Li; Xin Qi; Jia-Jie Zhu; Chen Huang; Shao-Ling Han; Qin Jiang; Tian-Le Xu; Jian-Hua Liu
Journal:  CNS Neurosci Ther       Date:  2018-05-20       Impact factor: 5.243

3.  Molecular basis of inhibition of acid sensing ion channel 1A by diminazene.

Authors:  Aram J Krauson; James G Rooney; Marcelo D Carattino
Journal:  PLoS One       Date:  2018-05-21       Impact factor: 3.240

4.  Acid-sensing ion channel 3: An analgesic target.

Authors:  Jasdip Singh Dulai; Ewan St John Smith; Taufiq Rahman
Journal:  Channels (Austin)       Date:  2021-12       Impact factor: 2.581

5.  Mechanosensory and mechanotransductive processes mediated by ion channels in articular chondrocytes: Potential therapeutic targets for osteoarthritis.

Authors:  Kun Zhang; Lifu Wang; Zhongcheng Liu; Bin Geng; Yuanjun Teng; Xuening Liu; Qiong Yi; Dechen Yu; Xiangyi Chen; Dacheng Zhao; Yayi Xia
Journal:  Channels (Austin)       Date:  2021-12       Impact factor: 2.581

Review 6.  Targeted Acid-Sensing Ion Channel Therapies for Migraine.

Authors:  Nazia Karsan; Eric B Gonzales; Gregory Dussor
Journal:  Neurotherapeutics       Date:  2018-04       Impact factor: 7.620

Review 7.  Animal, Herb, and Microbial Toxins for Structural and Pharmacological Study of Acid-Sensing Ion Channels.

Authors:  Dmitry I Osmakov; Timur A Khasanov; Yaroslav A Andreev; Ekaterina N Lyukmanova; Sergey A Kozlov
Journal:  Front Pharmacol       Date:  2020-07-08       Impact factor: 5.810
  7 in total

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