Kai-Tai Yip1, Nian-Yong Zhu, Dan Yang. 1. Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, PR China.
Abstract
Isoquinoline and quinoline have been discovered as novel ligands for palladium-catalyzed oxidative cascade cyclization reactions. With our new catalyst systems (Pd(OAc)(2)/isoquinoline or quinoline), unsaturated anilides cyclize under an oxygen atmosphere (1 atm) to furnish structurally versatile indoline derivatives in good yields. One C-N bond and two C-C bonds are formed in a single step with excellent diastereoselectivities (dr > 24:1).
Isoquinoline and n class="Chemical">quinoline have been discovered as novel ligands for palladium-catalyzed oxidative cascade cyclization reactions. With our new catalyst systems (Pd(OAc)(2)/isoquinoline or quinoline), unsaturated anilides cyclize under an oxygen atmosphere (1 atm) to furnish structurally versatile indoline derivatives in good yields. One C-N bond and two C-C bonds are formed in a single step with excellent diastereoselectivities (dr > 24:1).
Authors: Belén Vaz; Claudio Martínez; Francisco Cruz; J Gabriel Denis; Ángel R de Lera; José M Aurrecoechea; Rosana Álvarez Journal: J Org Chem Date: 2021-06-14 Impact factor: 4.354