Literature DB >> 19338079

Genetics of cardiac repolarization.

Svati H Shah1, Geoffrey S Pitt.   

Abstract

Prolongation of the electrocardiographic QT interval, a measure of cardiac repolarization, is associated with arrhythmogenic disorders and is a risk factor for sudden cardiac death. Two genome-wide association studies (GWAS) of variation in the QT interval in population-based cohorts now report association with variants in a subset of ion channel genes and other new associations.

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Year:  2009        PMID： 19338079     DOI： 10.1038/ng0409-388

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  12 in total

1.  QT interval in twins.

Authors:  N Carter; H Snieder; S Jeffery; R Saumarez; C Varma; L Antoniades; T D Spector
Journal:  J Hum Hypertens       Date:  2000-06       Impact factor: 3.012

2.  A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization.

Authors:  Dan E Arking; Arne Pfeufer; Wendy Post; W H Linda Kao; Christopher Newton-Cheh; Morna Ikeda; Kristen West; Carl Kashuk; Mahmut Akyol; Siegfried Perz; Shapour Jalilzadeh; Thomas Illig; Christian Gieger; Chao-Yu Guo; Martin G Larson; H Erich Wichmann; Eduardo Marbán; Christopher J O'Donnell; Joel N Hirschhorn; Stefan Kääb; Peter M Spooner; Thomas Meitinger; Aravinda Chakravarti
Journal:  Nat Genet       Date:  2006-04-30       Impact factor: 38.330

Review 3.  Long QT syndrome: reduced repolarization reserve and the genetic link.

Authors:  D M Roden
Journal:  J Intern Med       Date:  2006-01       Impact factor: 8.989

4.  Prolonged QTc interval and high B-type natriuretic peptide levels together predict mortality in patients with advanced heart failure.

Authors:  Bojan Vrtovec; Reynolds Delgado; Aly Zewail; Cynthia D Thomas; Barbara M Richartz; Branislav Radovancevic
Journal:  Circulation       Date:  2003-03-24       Impact factor: 29.690

5.  QT interval is a heritable quantitative trait with evidence of linkage to chromosome 3 in a genome-wide linkage analysis: The Framingham Heart Study.

Authors:  Christopher Newton-Cheh; Martin G Larson; Diane C Corey; Emelia J Benjamin; Alan G Herbert; Daniel Levy; Ralph B D'Agostino; Christopher J O'Donnell
Journal:  Heart Rhythm       Date:  2005-03       Impact factor: 6.343

6.  QT interval is linked to 2 long-QT syndrome loci in normal subjects.

Authors:  A Busjahn; H Knoblauch; H D Faulhaber; T Boeckel; M Rosenthal; R Uhlmann; M Hoehe; H Schuster; F C Luft
Journal:  Circulation       Date:  1999-06-22       Impact factor: 29.690

7.  Common NOS1AP variants are associated with a prolonged QTc interval in the Rotterdam Study.

Authors:  Albert-Jan L H J Aarnoudse; Christopher Newton-Cheh; Paul I W de Bakker; Sabine M J M Straus; Jan A Kors; Albert Hofman; André G Uitterlinden; Jacqueline C M Witteman; Bruno H C Stricker
Journal:  Circulation       Date:  2007-06-18       Impact factor: 29.690

8.  Association of NOS1AP genetic variants with QT interval duration in families from the Diabetes Heart Study.

Authors:  Allison B Lehtinen; Christopher Newton-Cheh; Julie T Ziegler; Carl D Langefeld; Barry I Freedman; Kurt R Daniel; David M Herrington; Donald W Bowden
Journal:  Diabetes       Date:  2008-01-30       Impact factor: 9.461

9.  QT interval prolongation predicts cardiovascular mortality in an apparently healthy population.

Authors:  E G Schouten; J M Dekker; P Meppelink; F J Kok; J P Vandenbroucke; J Pool
Journal:  Circulation       Date:  1991-10       Impact factor: 29.690

10.  Common variants at ten loci modulate the QT interval duration in the QTSCD Study.

Authors:  Arne Pfeufer; Serena Sanna; Dan E Arking; Martina Müller; Vesela Gateva; Christian Fuchsberger; Georg B Ehret; Marco Orrú; Cristian Pattaro; Anna Köttgen; Siegfried Perz; Gianluca Usala; Maja Barbalic; Man Li; Benno Pütz; Angelo Scuteri; Ronald J Prineas; Moritz F Sinner; Christian Gieger; Samer S Najjar; W H Linda Kao; Thomas W Mühleisen; Mariano Dei; Christine Happle; Stefan Möhlenkamp; Laura Crisponi; Raimund Erbel; Karl-Heinz Jöckel; Silvia Naitza; Gerhard Steinbeck; Fabio Marroni; Andrew A Hicks; Edward Lakatta; Bertram Müller-Myhsok; Peter P Pramstaller; H-Erich Wichmann; David Schlessinger; Eric Boerwinkle; Thomas Meitinger; Manuela Uda; Josef Coresh; Stefan Kääb; Gonçalo R Abecasis; Aravinda Chakravarti
Journal:  Nat Genet       Date:  2009-03-22       Impact factor: 38.330
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  3 in total

Review 1.  Five years of GWAS discovery.

Authors:  Peter M Visscher; Matthew A Brown; Mark I McCarthy; Jian Yang
Journal:  Am J Hum Genet       Date:  2012-01-13       Impact factor: 11.025

2.  Genome partitioning of genetic variation for complex traits using common SNPs.

Authors:  Jian Yang; Teri A Manolio; Louis R Pasquale; Eric Boerwinkle; Neil Caporaso; Julie M Cunningham; Mariza de Andrade; Bjarke Feenstra; Eleanor Feingold; M Geoffrey Hayes; William G Hill; Maria Teresa Landi; Alvaro Alonso; Guillaume Lettre; Peng Lin; Hua Ling; William Lowe; Rasika A Mathias; Mads Melbye; Elizabeth Pugh; Marilyn C Cornelis; Bruce S Weir; Michael E Goddard; Peter M Visscher
Journal:  Nat Genet       Date:  2011-05-08       Impact factor: 38.330

Review 3.  Ion channel associated diseases: overview of molecular mechanisms.

Authors:  Mark A Zaydman; Jonathan R Silva; Jianmin Cui
Journal:  Chem Rev       Date:  2012-11-14       Impact factor: 60.622
  3 in total

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