Literature DB >> 19333867

The biosynthetic potential of myxobacteria and their impact in drug discovery.

Silke C Wenzel1, Rolf Müller.   

Abstract

Myxobacteria produce an immense variety of natural products with useful biological activities. This review highlights recent advances to evaluate and further explore their biosynthetic potential for drug discovery, with particular focus on polyketide synthase and non-ribosomal peptide synthetase-derived secondary metabolites.

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Year:  2009        PMID： 19333867

Source DB:  PubMed          Journal:  Curr Opin Drug Discov Devel        ISSN： 1367-6733


  20 in total

1.  Comprehensive set of integrative plasmid vectors for copper-inducible gene expression in Myxococcus xanthus.

Authors:  Nuria Gómez-Santos; Anke Treuner-Lange; Aurelio Moraleda-Muñoz; Elena García-Bravo; Raquel García-Hernández; Marina Martínez-Cayuela; Juana Pérez; Lotte Søgaard-Andersen; José Muñoz-Dorado
Journal:  Appl Environ Microbiol       Date:  2012-01-27       Impact factor: 4.792

Review 2.  Activating the expression of bacterial cryptic genes by rpoB mutations in RNA polymerase or by rare earth elements.

Authors:  Kozo Ochi; Yukinori Tanaka; Shigeo Tojo
Journal:  J Ind Microbiol Biotechnol       Date:  2013-10-15       Impact factor: 3.346

3.  Discovery of scmR as a global regulator of secondary metabolism and virulence in Burkholderia thailandensis E264.

Authors:  Dainan Mao; Leah B Bushin; Kyuho Moon; Yihan Wu; Mohammad R Seyedsayamdost
Journal:  Proc Natl Acad Sci U S A       Date:  2017-03-20       Impact factor: 11.205

4.  Activation and products of the cryptic secondary metabolite biosynthetic gene clusters by rifampin resistance (rpoB) mutations in actinomycetes.

Authors:  Yukinori Tanaka; Ken Kasahara; Yutaka Hirose; Kiriko Murakami; Rie Kugimiya; Kozo Ochi
Journal:  J Bacteriol       Date:  2013-04-19       Impact factor: 3.490

5.  Antimalarial activity of the myxobacterial macrolide chlorotonil a.

Authors:  Jana Held; Tamirat Gebru; Markus Kalesse; Rolf Jansen; Klaus Gerth; Rolf Müller; Benjamin Mordmüller
Journal:  Antimicrob Agents Chemother       Date:  2014-08-11       Impact factor: 5.191

6.  Fatty acid-related phylogeny of myxobacteria as an approach to discover polyunsaturated omega-3/6 Fatty acids.

Authors:  Ronald Garcia; Dominik Pistorius; Marc Stadler; Rolf Müller
Journal:  J Bacteriol       Date:  2011-02-11       Impact factor: 3.490

7.  Marine myxobacteria as a source of antibiotics--comparison of physiology, polyketide-type genes and antibiotic production of three new isolates of Enhygromyxa salina.

Authors:  Till F Schäberle; Emilie Goralski; Edith Neu; Ozlem Erol; Georg Hölzl; Peter Dörmann; Gabriele Bierbaum; Gabriele M König
Journal:  Mar Drugs       Date:  2010-09-03       Impact factor: 5.118

8.  Characterization of a novel type of oxidative decarboxylase involved in the biosynthesis of the styryl moiety of chondrochloren from an acylated tyrosine.

Authors:  Shwan Rachid; Ole Revermann; Christina Dauth; Uli Kazmaier; Rolf Müller
Journal:  J Biol Chem       Date:  2010-01-15       Impact factor: 5.157

Review 9.  Antibiotics for emerging pathogens.

Authors:  Michael A Fischbach; Christopher T Walsh
Journal:  Science       Date:  2009-08-28       Impact factor: 47.728

10.  Chimaeric load among sympatric social bacteria increases with genotype richness.

Authors:  Helena Mendes-Soares; I-Chen Kimberly Chen; Kara Fitzpatrick; Gregory J Velicer
Journal:  Proc Biol Sci       Date:  2014-07-22       Impact factor: 5.349
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