Literature DB >> 19332878

Precise gene-dose alleles for chemical genetics.

Zhun Yan1, Nicolas M Berbenetz, Guri Giaever, Corey Nislow.   

Abstract

Modulating gene dose is an effective way to alter protein levels and modify phenotypes to understand gene function. In addition, combining gene-dose alleles with chemical perturbation can provide insight into drug-gene interactions. Here, we present a strategy that combines diverse loss-of-function alleles to systematically modulate gene dose in Saccharomyces cerevisiae. The generated gene dosage allele set expands the genetic toolkit for uncovering novel phenotypes.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19332878      PMCID： PMC2691769          DOI： 10.1534/genetics.109.103036

Source DB:  PubMed          Journal:  Genetics        ISSN： 0016-6731            Impact factor:   4.562


  18 in total

1.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

Authors:  K J Livak; T D Schmittgen
Journal:  Methods       Date:  2001-12       Impact factor: 3.608

2.  Assumption-free analysis of quantitative real-time polymerase chain reaction (PCR) data.

Authors:  Christian Ramakers; Jan M Ruijter; Ronald H Lekanne Deprez; Antoon F M Moorman
Journal:  Neurosci Lett       Date:  2003-03-13       Impact factor: 3.046

3.  Chemogenomic profiling: identifying the functional interactions of small molecules in yeast.

Authors:  Guri Giaever; Patrick Flaherty; Jochen Kumm; Michael Proctor; Corey Nislow; Daniel F Jaramillo; Angela M Chu; Michael I Jordan; Adam P Arkin; Ronald W Davis
Journal:  Proc Natl Acad Sci U S A       Date:  2004-01-12       Impact factor: 11.205

4.  Exploration of essential gene functions via titratable promoter alleles.

Authors:  Sanie Mnaimneh; Armaity P Davierwala; Jennifer Haynes; Jason Moffat; Wen-Tao Peng; Wen Zhang; Xueqi Yang; Jeff Pootoolal; Gordon Chua; Andres Lopez; Miles Trochesset; Darcy Morse; Nevan J Krogan; Shawna L Hiley; Zhijian Li; Quaid Morris; Jörg Grigull; Nicholas Mitsakakis; Christopher J Roberts; Jack F Greenblatt; Charles Boone; Chris A Kaiser; Brenda J Andrews; Timothy R Hughes
Journal:  Cell       Date:  2004-07-09       Impact factor: 41.582

5.  Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile.

Authors:  Maya Schuldiner; Sean R Collins; Natalie J Thompson; Vladimir Denic; Arunashree Bhamidipati; Thanuja Punna; Jan Ihmels; Brenda Andrews; Charles Boone; Jack F Greenblatt; Jonathan S Weissman; Nevan J Krogan
Journal:  Cell       Date:  2005-11-04       Impact factor: 41.582

6.  Mechanisms of haploinsufficiency revealed by genome-wide profiling in yeast.

Authors:  Adam M Deutschbauer; Daniel F Jaramillo; Michael Proctor; Jochen Kumm; Maureen E Hillenmeyer; Ronald W Davis; Corey Nislow; Guri Giaever
Journal:  Genetics       Date:  2005-02-16       Impact factor: 4.562

7.  Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis.

Authors:  E A Winzeler; D D Shoemaker; A Astromoff; H Liang; K Anderson; B Andre; R Bangham; R Benito; J D Boeke; H Bussey; A M Chu; C Connelly; K Davis; F Dietrich; S W Dow; M El Bakkoury; F Foury; S H Friend; E Gentalen; G Giaever; J H Hegemann; T Jones; M Laub; H Liao; N Liebundguth; D J Lockhart; A Lucau-Danila; M Lussier; N M'Rabet; P Menard; M Mittmann; C Pai; C Rebischung; J L Revuelta; L Riles; C J Roberts; P Ross-MacDonald; B Scherens; M Snyder; S Sookhai-Mahadeo; R K Storms; S Véronneau; M Voet; G Volckaert; T R Ward; R Wysocki; G S Yen; K Yu; K Zimmermann; P Philippsen; M Johnston; R W Davis
Journal:  Science       Date:  1999-08-06       Impact factor: 47.728

8.  Genomic profiling of drug sensitivities via induced haploinsufficiency.

Authors:  G Giaever; D D Shoemaker; T W Jones; H Liang; E A Winzeler; A Astromoff; R W Davis
Journal:  Nat Genet       Date:  1999-03       Impact factor: 38.330

9.  Yeast genome-wide drug-induced haploinsufficiency screen to determine drug mode of action.

Authors:  Kristin Baetz; Lianne McHardy; Ken Gable; Tamsin Tarling; Delphine Rebérioux; Jenny Bryan; Raymond J Andersen; Teresa Dunn; Phil Hieter; Michel Roberge
Journal:  Proc Natl Acad Sci U S A       Date:  2004-03-15       Impact factor: 11.205

10.  Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes.

Authors:  Pek Yee Lum; Christopher D Armour; Sergey B Stepaniants; Guy Cavet; Maria K Wolf; J Scott Butler; Jerald C Hinshaw; Philippe Garnier; Glenn D Prestwich; Amy Leonardson; Philip Garrett-Engele; Christopher M Rush; Martin Bard; Greg Schimmack; John W Phillips; Christopher J Roberts; Daniel D Shoemaker
Journal:  Cell       Date:  2004-01-09       Impact factor: 41.582
View more
  10 in total

1.  Allele interaction--single locus genetics meets regulatory biology.

Authors:  Arne B Gjuvsland; Erik Plahte; Tormod Adnøy; Stig W Omholt
Journal:  PLoS One       Date:  2010-02-23       Impact factor: 3.240

2.  Linking yeast Gcn5p catalytic function and gene regulation using a quantitative, graded dominant mutant approach.

Authors:  Amanda M Lanza; John J Blazeck; Nathan C Crook; Hal S Alper
Journal:  PLoS One       Date:  2012-04-27       Impact factor: 3.240

3.  Cross-species discovery of syncretic drug combinations that potentiate the antifungal fluconazole.

Authors:  Michaela Spitzer; Emma Griffiths; Kim M Blakely; Jan Wildenhain; Linda Ejim; Laura Rossi; Gianfranco De Pascale; Jasna Curak; Eric Brown; Mike Tyers; Gerard D Wright
Journal:  Mol Syst Biol       Date:  2011-06-21       Impact factor: 11.429

Review 4.  Functional toxicogenomics: mechanism-centered toxicology.

Authors:  Matthew North; Chris D Vulpe
Journal:  Int J Mol Sci       Date:  2010-11-24       Impact factor: 5.923

5.  Genome-Wide Screen Reveals sec21 Mutants of Saccharomyces cerevisiae Are Methotrexate-Resistant.

Authors:  Lai H Wong; Stephane Flibotte; Sunita Sinha; Jennifer Chiang; Guri Giaever; Corey Nislow
Journal:  G3 (Bethesda)       Date:  2017-04-03       Impact factor: 3.154

6.  Network dynamics of the yeast methyltransferome.

Authors:  Guri Giaever; Elena Lissina; Corey Nislow
Journal:  Microb Cell       Date:  2019-07-09

7.  Ontology-based cross-species integration and analysis of Saccharomyces cerevisiae phenotypes.

Authors:  Georgios V Gkoutos; Robert Hoehndorf
Journal:  J Biomed Semantics       Date:  2012-09-21

Review 8.  Forward chemical genetics in yeast for discovery of chemical probes targeting metabolism.

Authors:  Robert St Onge; Ulrich Schlecht; Curt Scharfe; Marie Evangelista
Journal:  Molecules       Date:  2012-11-05       Impact factor: 4.411

9.  Lithium Chloride Sensitivity in Yeast and Regulation of Translation.

Authors:  Maryam Hajikarimlou; Kathryn Hunt; Grace Kirby; Sarah Takallou; Sasi Kumar Jagadeesan; Katayoun Omidi; Mohsen Hooshyar; Daniel Burnside; Houman Moteshareie; Mohan Babu; Myron Smith; Martin Holcik; Bahram Samanfar; Ashkan Golshani
Journal:  Int J Mol Sci       Date:  2020-08-10       Impact factor: 5.923

10.  An inducible CRISPR interference library for genetic interrogation of Saccharomyces cerevisiae biology.

Authors:  Amir Momen-Roknabadi; Panos Oikonomou; Maxwell Zegans; Saeed Tavazoie
Journal:  Commun Biol       Date:  2020-11-27
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.