Literature DB >> 19332336

The ketogenic diet: proposed mechanisms of action.

Kirk Nylen1, Sergei Likhodii, W McIntyre Burnham.   

Abstract

The ketogenic diet is a high-fat, low-carbohydrate diet used to treat drug-resistant seizures, especially in children. A number of possible mechanisms of action have been proposed to explain the anticonvulsant effects of the diet. Four of these hypothetical mechanisms are discussed in the present article: the pH hypothesis, the metabolic hypotheses, the amino acid hypothesis, and the ketone hypothesis.

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Year:  2009        PMID： 19332336      PMCID： PMC5084220          DOI： 10.1016/j.nurt.2009.01.021

Source DB:  PubMed          Journal:  Neurotherapeutics        ISSN： 1878-7479            Impact factor:   7.620


  17 in total

Review 1.  Gap junctions, synchrony and seizures.

Authors:  J L Perez Velazquez; P L Carlen
Journal:  Trends Neurosci       Date:  2000-02       Impact factor: 13.837

Review 2.  The use of diet in the treatment of epilepsy.

Authors:  Elizabeth E Bailey; Heidi H Pfeifer; Elizabeth A Thiele
Journal:  Epilepsy Behav       Date:  2005-02       Impact factor: 2.937

3.  Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet.

Authors:  Kristopher J Bough; Jonathon Wetherington; Bjørnar Hassel; Jean Francois Pare; Jeremy W Gawryluk; James G Greene; Renee Shaw; Yoland Smith; Jonathan D Geiger; Raymond J Dingledine
Journal:  Ann Neurol       Date:  2006-08       Impact factor: 10.422

Review 4.  Clinical efficacy of the ketogenic diet.

Authors:  E P Vining
Journal:  Epilepsy Res       Date:  1999-12       Impact factor: 3.045

5.  Acetoacetate, acetone, and dibenzylamine (a contaminant in l-(+)-beta-hydroxybutyrate) exhibit direct anticonvulsant actions in vivo.

Authors:  Jong M Rho; Gail D Anderson; Sean D Donevan; H Steve White
Journal:  Epilepsia       Date:  2002-04       Impact factor: 5.864

Review 6.  Non-invasive detection of ketosis and its application in refractory epilepsy.

Authors:  K Musa-Veloso
Journal:  Prostaglandins Leukot Essent Fatty Acids       Date:  2004-03       Impact factor: 4.006

Review 7.  Brain uptake and metabolism of ketone bodies in animal models.

Authors:  Astrid Nehlig
Journal:  Prostaglandins Leukot Essent Fatty Acids       Date:  2004-03       Impact factor: 4.006

8.  Diet-induced ketosis does not cause cerebral acidosis.

Authors:  A S Al-Mudallal; J C LaManna; W D Lust; S I Harik
Journal:  Epilepsia       Date:  1996-03       Impact factor: 5.864

9.  Fructose-1,6-bisphosphate has anticonvulsant activity in models of acute seizures in adult rats.

Authors:  Xiao-Yuan Lian; Firdous A Khan; Janet L Stringer
Journal:  J Neurosci       Date:  2007-10-31       Impact factor: 6.167

Review 10.  The neuropharmacology of the ketogenic diet.

Authors:  Adam L Hartman; Maciej Gasior; Eileen P G Vining; Michael A Rogawski
Journal:  Pediatr Neurol       Date:  2007-05       Impact factor: 3.372
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  9 in total

1.  Purines and the Anti-Epileptic Actions of Ketogenic Diets.

Authors:  Susan A Masino; Masahito Kawamura; David N Ruskin; Jeremy Gawryluk; Xuesong Chen; Jonathan D Geiger
Journal:  Open Neurosci J       Date:  2010-01-01

2.  Ketogenic diet: rapid onset of selenium deficiency-induced cardiac decompensation.

Authors:  Naga S Sirikonda; William D Patten; John R Phillips; Charles J Mullett
Journal:  Pediatr Cardiol       Date:  2012-02-25       Impact factor: 1.655

3.  A ketogenic diet reduces long-term potentiation in the dentate gyrus of freely behaving rats.

Authors:  Jessica L Koranda; David N Ruskin; Susan A Masino; J Harry Blaise
Journal:  J Neurophysiol       Date:  2011-05-25       Impact factor: 2.714

Review 4.  The neuropathology of obesity: insights from human disease.

Authors:  Edward B Lee; Mark P Mattson
Journal:  Acta Neuropathol       Date:  2013-10-06       Impact factor: 17.088

Review 5.  Adenosine receptors and epilepsy: current evidence and future potential.

Authors:  Susan A Masino; Masahito Kawamura; David N Ruskin
Journal:  Int Rev Neurobiol       Date:  2014       Impact factor: 3.230

6.  Effects of infantile repeated hyperglycemia on neuronal density of hippocampus and pentylentetrazol induced convulsions in male wistar rats.

Authors:  Malihe Moghadami; Ali Moghimi; Razieh Jalal; Morteza Behnam-Rasouli; Naser Mahdavi-Shahri
Journal:  Iran J Basic Med Sci       Date:  2012-07       Impact factor: 2.699

Review 7.  Neuroactive peptides as putative mediators of antiepileptic ketogenic diets.

Authors:  Carmela Giordano; Maddalena Marchiò; Elena Timofeeva; Giuseppe Biagini
Journal:  Front Neurol       Date:  2014-04-29       Impact factor: 4.003

Review 8.  Ketogenic diet in endocrine disorders: Current perspectives.

Authors:  L Gupta; D Khandelwal; S Kalra; P Gupta; D Dutta; S Aggarwal
Journal:  J Postgrad Med       Date:  2017 Oct-Dec       Impact factor: 1.476

9.  Incidence and Characteristics of Kidney Stones in Patients on Ketogenic Diet: A Systematic Review and Meta-Analysis.

Authors:  Prakrati Acharya; Chirag Acharya; Charat Thongprayoon; Panupong Hansrivijit; Swetha R Kanduri; Karthik Kovvuru; Juan Medaura; Pradeep Vaitla; Desiree F Garcia Anton; Poemlarp Mekraksakit; Pattharawin Pattharanitima; Tarun Bathini; Wisit Cheungpasitporn
Journal:  Diseases       Date:  2021-05-25
  9 in total

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