| Literature DB >> 19329309 |
Darrin W Hopper1, Matthew D Vera, David How, Joshua Sabatini, Jason S Xiang, Manus Ipek, Jennifer Thomason, Yonghan Hu, Eric Feyfant, Qin Wang, Katy E Georgiadis, Erica Reifenberg, Richard T Sheldon, Cristin C Keohan, Manas K Majumdar, Elisabeth A Morris, Jerauld Skotnicki, Phaik-Eng Sum.
Abstract
The prevention of aggrecan (a key component of cartilage) cleavage via the inhibition of aggrecanase-1 may provide a unique opportunity to stop the progression of cartilage degradation in osteoarthritis. The evaluation of a series of biphenylsulfonamides resulted in the identification of the ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides analogs (19-21 and 24) with improved Agg-1 inhibition and MMP-2, MMP-13 activity.Entities:
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Year: 2009 PMID： 19329309 DOI： 10.1016/j.bmcl.2009.03.056
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823