Literature DB >> 19328751

Simultaneous determination of four tobacco-specific N-nitrosamines (TSNA) in human urine.

Dominique Kavvadias1, Gerhard Scherer, Michael Urban, Francis Cheung, Graham Errington, Jim Shepperd, Mike McEwan.   

Abstract

Tobacco-specific N-nitrosamines (TSNA) include 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), N-nitrosonornicotine (NNN), N-nitrosoanabasine (NAB) and N-nitrosoanatabine (NAT). TSNA are suggested to play an important role in tobacco smoke carcinogenesis. We have developed and validated an LC-MS/MS method for the determination of total (free and conjugated) TSNA in human urine. The limits of detection (LOD) were 2.0, 0.8, 1.1 and 0.7 pg/ml for NNAL, NNN, NAB and NAT, respectively. Smokers were found to have significantly higher levels of TSNA in their urine than nonsmokers. In conclusion, the newly developed method is suitable for assessing the tobacco use-related exposure to NNK, NNN, NAB and NAT.

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Year:  2009        PMID： 19328751     DOI： 10.1016/j.jchromb.2009.03.009

Source DB:  PubMed          Journal:  J Chromatogr B Analyt Technol Biomed Life Sci        ISSN： 1570-0232            Impact factor:   3.205


  15 in total

1.  Temporal stability of urinary and plasma biomarkers of tobacco smoke exposure among cigarette smokers.

Authors:  Timothy R Church; Kristin E Anderson; Chap Le; Yan Zhang; Diane M Kampa; Adam R Benoit; Andrea R Yoder; Steven G Carmella; Stephen S Hecht
Journal:  Biomarkers       Date:  2010-06       Impact factor: 2.658

2.  High throughput liquid and gas chromatography-tandem mass spectrometry assays for tobacco-specific nitrosamine and polycyclic aromatic hydrocarbon metabolites associated with lung cancer in smokers.

Authors:  Steven G Carmella; Xun Ming; Natalie Olvera; Claire Brookmeyer; Andrea Yoder; Stephen S Hecht
Journal:  Chem Res Toxicol       Date:  2013-07-24       Impact factor: 3.739

3.  A new liquid chromatography/mass spectrometry method for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in urine.

Authors:  Showket H Bhat; Stacy L Gelhaus; Clementina Mesaros; Anil Vachani; Ian A Blair
Journal:  Rapid Commun Mass Spectrom       Date:  2011-01-15       Impact factor: 2.419

4.  Applying tobacco carcinogen and toxicant biomarkers in product regulation and cancer prevention.

Authors:  Stephen S Hecht; Jian-Min Yuan; Dorothy Hatsukami
Journal:  Chem Res Toxicol       Date:  2010-06-21       Impact factor: 3.739

5.  Genetic variability in the metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) to 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL).

Authors:  Monica Ter-Minassian; Kofi Asomaning; Yang Zhao; Feng Chen; Li Su; Steven G Carmella; Xihong Lin; Stephen S Hecht; David C Christiani
Journal:  Int J Cancer       Date:  2011-08-03       Impact factor: 7.396

6.  Formation, repair, and genotoxic properties of bulky DNA adducts formed from tobacco-specific nitrosamines.

Authors:  Lisa A Peterson
Journal:  J Nucleic Acids       Date:  2010-09-05

7.  Combined analysis of N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in the urine of cigarette smokers and e-cigarette users.

Authors:  Delshanee Kotandeniya; Steven G Carmella; Makenzie E Pillsbury; Stephen S Hecht
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2015-10-31       Impact factor: 3.205

8.  Tobacco-specific nitrosamine exposures in smokers and nonsmokers exposed to cigarette or waterpipe tobacco smoke.

Authors:  Ghada Radwan; Stephen S Hecht; Steven G Carmella; Christopher A Loffredo
Journal:  Nicotine Tob Res       Date:  2012-05-09       Impact factor: 4.244

9.  Characterization of molecularly imprinted polymers for the extraction of tobacco alkaloids and their metabolites in human urine.

Authors:  Haley A Mulder; Adam C Pearcy; Matthew S Halquist
Journal:  Biomed Chromatogr       Date:  2022-04-26       Impact factor: 1.911

10.  Bioanalysis in drug discovery and development.

Authors:  Saurabh Pandey; Preeti Pandey; Gaurav Tiwari; Ruchi Tiwari
Journal:  Pharm Methods       Date:  2010-10
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