Literature DB >> 19328202

Estrogen receptor-alpha (ER-alpha) suppresses expression of its variant ER-alpha 36.

Yi Zou1, Ling Ding, Megan Coleman, Zhaoyi Wang.   

Abstract

Recently, we identified and cloned a membrane-based estrogen receptor (ER), ER-alpha 36, which is transcribed from a previously unidentified promoter in the first intron of the original ER-alpha gene. We cloned the 5' flanking region of ER-alpha 36 and found the cloned DNA sequence possessed strong promoter activity. A single transcription initiation site was mapped and a number of putative regulatory elements for various transcription factors such as the Wilms' tumor suppressor, WT1 and estrogen receptor (ER) were identified in this region. Transient co-transfection experiments further demonstrated that ER-alpha suppresses ER-alpha 36 promoter activity in an estrogen-independent manner, which can be released by ER-alpha 36 itself.

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Year:  2009        PMID： 19328202      PMCID： PMC2737280          DOI： 10.1016/j.febslet.2009.03.047

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  24 in total

Review 1.  Estrogen action and cytoplasmic signaling pathways. Part II: the role of growth factors and phosphorylation in estrogen signaling.

Authors:  Paul H Driggers; James H Segars
Journal:  Trends Endocrinol Metab       Date:  2002-12       Impact factor: 12.015

Review 2.  Estrogen action and cytoplasmic signaling cascades. Part I: membrane-associated signaling complexes.

Authors:  James H Segars; Paul H Driggers
Journal:  Trends Endocrinol Metab       Date:  2002-10       Impact factor: 12.015

Review 3.  Estrogen receptor pathways to AP-1.

Authors:  P J Kushner; D A Agard; G L Greene; T S Scanlan; A K Shiau; R M Uht; P Webb
Journal:  J Steroid Biochem Mol Biol       Date:  2000-11-30       Impact factor: 4.292

4.  Estrogen receptor alpha interaction with estrogen response element half-sites from the rat prolactin gene.

Authors:  I Anderson; J Gorski
Journal:  Biochemistry       Date:  2000-04-04       Impact factor: 3.162

5.  Identification of a new isoform of the human estrogen receptor-alpha (hER-alpha) that is encoded by distinct transcripts and that is able to repress hER-alpha activation function 1.

Authors:  G Flouriot; H Brand; S Denger; R Metivier; M Kos; G Reid; V Sonntag-Buck; F Gannon
Journal:  EMBO J       Date:  2000-09-01       Impact factor: 11.598

Review 6.  Estrogen receptor interaction with estrogen response elements.

Authors:  C M Klinge
Journal:  Nucleic Acids Res       Date:  2001-07-15       Impact factor: 16.971

7.  BRCA1 mediates ligand-independent transcriptional repression of the estrogen receptor.

Authors:  L Zheng; L A Annab; C A Afshari; W H Lee; T G Boyer
Journal:  Proc Natl Acad Sci U S A       Date:  2001-08-07       Impact factor: 11.205

8.  Sp1 binding sites and an estrogen response element half-site are involved in regulation of the human progesterone receptor A promoter.

Authors:  L N Petz; A M Nardulli
Journal:  Mol Endocrinol       Date:  2000-07

Review 9.  Cellular functions of plasma membrane estrogen receptors.

Authors:  Ellis R Levin
Journal:  Steroids       Date:  2002-05       Impact factor: 2.668

10.  ER-alpha36, a novel variant of ER-alpha, is expressed in ER-positive and -negative human breast carcinomas.

Authors:  Lisa M J Lee; Jiang Cao; Hao Deng; Ping Chen; Zoran Gatalica; Zhao-Yi Wang
Journal:  Anticancer Res       Date:  2008 Jan-Feb       Impact factor: 2.480
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  42 in total

1.  Opposite regulation of estrogen receptor-α and its variant ER-α36 by the Wilms' tumor suppressor WT1.

Authors:  Lianguo Kang; Lei Wang; Zhao-Yi Wang
Journal:  Oncol Lett       Date:  2011-01-21       Impact factor: 2.967

2.  Involvement of ER-α36, Src, EGFR and STAT5 in the biphasic estrogen signaling of ER-negative breast cancer cells.

Authors:  Xin-Tian Zhang; Ling Ding; Lian-Guo Kang; Zhao-Yi Wang
Journal:  Oncol Rep       Date:  2012-03-15       Impact factor: 3.906

3.  Downregulation of ER-α36 expression sensitizes HER2 overexpressing breast cancer cells to tamoxifen.

Authors:  Li Yin; Xiaohua Pan; Xin-Tian Zhang; Yu-Ming Guo; Zhao-Yi Wang; Yaoqin Gong; Molin Wang
Journal:  Am J Cancer Res       Date:  2015-01-15       Impact factor: 6.166

4.  GPR30 is necessary for estradiol-induced desensitization of 5-HT1A receptor signaling in the paraventricular nucleus of the rat hypothalamus.

Authors:  C E McAllister; R D Creech; P A Kimball; N A Muma; Q Li
Journal:  Psychoneuroendocrinology       Date:  2012-01-20       Impact factor: 4.905

5.  Synuclein gamma stimulates membrane-initiated estrogen signaling by chaperoning estrogen receptor (ER)-alpha36, a variant of ER-alpha.

Authors:  Yuenian Eric Shi; Yiding Chen; Raduwan Dackour; Louis Potters; Shui Wang; Qiang Ding; Zhaoyi Wang; Yiliang Ellie Liu
Journal:  Am J Pathol       Date:  2010-07-01       Impact factor: 4.307

6.  MicroRNA-335-5p and -3p synergize to inhibit estrogen receptor alpha expression and promote tamoxifen resistance.

Authors:  Elizabeth C Martin; Adrienne K Conger; Thomas J Yan; Van T Hoang; David F B Miller; Aaron Buechlein; Douglas B Rusch; Kenneth P Nephew; Bridgette M Collins-Burow; Matthew E Burow
Journal:  FEBS Lett       Date:  2017-01-12       Impact factor: 4.124

7.  Estrogen receptor-α36 is involved in development of acquired tamoxifen resistance via regulating the growth status switch in breast cancer cells.

Authors:  Guangliang Li; Jing Zhang; Ketao Jin; Kuifeng He; Yi Zheng; Xin Xu; Haohao Wang; Haiyong Wang; Zhongqi Li; Xiongfei Yu; Xiaodong Teng; Jiang Cao; Lisong Teng
Journal:  Mol Oncol       Date:  2013-02-26       Impact factor: 6.603

8.  Breast cancer cell growth inhibition by phenethyl isothiocyanate is associated with down-regulation of oestrogen receptor-alpha36.

Authors:  Lianguo Kang; Zhao-Yi Wang
Journal:  J Cell Mol Med       Date:  2009-10-15       Impact factor: 5.310

9.  ER-α36, a novel variant of ER-α, mediates estrogen-stimulated proliferation of endometrial carcinoma cells via the PKCδ/ERK pathway.

Authors:  Jing-Shan Tong; Qing-Hua Zhang; Zhen-Bo Wang; Sen Li; Cai-Rong Yang; Xue-Qi Fu; Yi Hou; Zhao-Yi Wang; Jun Sheng; Qing-Yuan Sun
Journal:  PLoS One       Date:  2010-11-04       Impact factor: 3.240

10.  A novel variant of ER-alpha, ER-alpha36 mediates testosterone-stimulated ERK and Akt activation in endometrial cancer Hec1A cells.

Authors:  Sheng-Li Lin; Li-Ying Yan; Xing-Wei Liang; Zhen-Bo Wang; Zhao-Yi Wang; Jie Qiao; Heide Schatten; Qing-Yuan Sun
Journal:  Reprod Biol Endocrinol       Date:  2009-09-24       Impact factor: 5.211
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