| Literature DB >> 19328058 |
Abstract
Bax inhibitor-1 (BI-1) interacts with Bax, neutralizing its proapoptotic activity. In this issue of Molecular Cell, Lisbona et al. (2009) show that BI-1 directly inhibits IRE1alpha, an essential mediator of the UPR, thereby facilitating crosstalk between apoptosis and ER stress pathways.Entities:
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Year: 2009 PMID: 19328058 DOI: 10.1016/j.molcel.2009.03.002
Source DB: PubMed Journal: Mol Cell ISSN: 1097-2765 Impact factor: 17.970