| Literature DB >> 19327406 |
Nancy Garbacki1, Emmanuel Di Valentin, Jacques Piette, Didier Cataldo, Céline Crahay, Alain Colige.
Abstract
Among the large matrix metalloproteinases (MMPs) family, MMP-12, also referred to as macrophage elastase, plays a significant role in chronic pulmonary pathologies characterized by an intense tissue remodeling such as asthma and COPD. This review will summarize knowledge about MMP-12 structure, functions and mechanisms of activation and regulation, including potential MMP-12 modulation by microRNA. As MMP-12 is involved in many tissue remodeling diseases, efforts have been made to develop specific synthetic inhibitors. However, at this time, very few chemical inhibitors have proved to be efficient and specific to a particular MMP. The relevance of silencing MMP-12 by RNA interference is highlighted. The specificity of this approach using siRNA or shRNA and the strategies to deliver these molecules in the lung are discussed.Entities:
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Year: 2009 PMID： 19327406 DOI： 10.1016/j.pupt.2009.03.001
Source DB: PubMed Journal: Pulm Pharmacol Ther ISSN： 1094-5539 Impact factor: 3.410