| Literature DB >> 1932395 |
C M Mazure1, J C Nelson, P I Jatlow, M B Bowers.
Abstract
The relationship of plasma free homovanillic acid (HVA) and methoxyhydroxyphenylglycol (MHPG) to early clinical response was prospectively studied in a new series of acutely psychotic inpatients given a fixed dose of perphenazine elixir for 10 days. Elevated pretreatment plasma HVA but not MHPG was significantly associated with good response. Change in HVA was correlated with a favorable response and a significant decline in MHPG was found in responders. Results suggest that HVA can provide a useful clinical predictor of response, and that both dopamine metabolism and noradrenergic functioning, as measured by plasma HVA and MHPG, are reduced in effective neuroleptic treatment.Entities:
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Year: 1991 PMID： 1932395 DOI： 10.1016/0006-3223(91)90309-a
Source DB: PubMed Journal: Biol Psychiatry ISSN： 0006-3223 Impact factor: 13.382