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Literature DB >> 19321388

Advances in the pathogenesis and treatment of IBD.

Abstract

Crohn's disease and ulcerative colitis are chronic remitting and relapsing inflammatory bowel diseases. We present a typical case of Crohn's disease in a young woman and discuss potential treatment options. Crohn's disease and ulcerative colitis likely result from interaction of multiple genetic and environmental risk and protective factors. Both are diseases ultimately caused by immune dysregulation. Medical therapy is with mesalamine compounds, corticosteroids, immunomodulators and/or biologics that target TNFalpha signaling or alpha4-integrin-mediated trafficking. Investigational agents include those targeted against other cytokines and costimulatory molecules or designed to promote immune regulation such as exposure to helminths which is a focus of this review.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2009 PMID： 19321388 PMCID： PMC2693446 DOI： 10.1016/j.clim.2009.02.006

Source DB: PubMed Journal: Clin Immunol ISSN： 1521-6616 Impact factor: 3.969

93 in total

Review 1. Oral 5-aminosalicylic acid for maintenance of remission in ulcerative colitis.

Authors: L Sutherland; J K Macdonald
Journal: Cochrane Database Syst Rev Date: 2006-04-19

Review 2. A successful experience of soil-transmitted helminth control in the Republic of Korea.

Authors: Sung-Tae Hong; Jong-Yil Chai; Min-Ho Choi; Sun Huh; Han-Jong Rim; Soon-Hyung Lee
Journal: Korean J Parasitol Date: 2006-09 Impact factor: 1.341

3. A population-based ecologic study of inflammatory bowel disease: searching for etiologic clues.

Authors: Chris Green; Lawrence Elliott; Carole Beaudoin; Charles N Bernstein
Journal: Am J Epidemiol Date: 2006-08-18 Impact factor: 4.897

4. Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology.

Authors: Holm H Uhlig; Brent S McKenzie; Sophie Hue; Claire Thompson; Barbara Joyce-Shaikh; Renata Stepankova; Nicolas Robinson; Sofia Buonocore; Helena Tlaskalova-Hogenova; Daniel J Cua; Fiona Powrie
Journal: Immunity Date: 2006-08 Impact factor: 31.745

5. Human IRGM induces autophagy to eliminate intracellular mycobacteria.

Authors: Sudha B Singh; Alexander S Davis; Gregory A Taylor; Vojo Deretic
Journal: Science Date: 2006-08-03 Impact factor: 47.728

6. Induction of CD8+ regulatory T cells in the intestine by Heligmosomoides polygyrus infection.

Authors: Ahmed Metwali; Tommy Setiawan; Arthur M Blum; Joseph Urban; David E Elliott; Long Hang; Joel V Weinstock
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2006-08 Impact factor: 4.052

Review 7. Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm.

Authors: Jeffrey Bethony; Simon Brooker; Marco Albonico; Stefan M Geiger; Alex Loukas; David Diemert; Peter J Hotez
Journal: Lancet Date: 2006-05-06 Impact factor: 79.321

8. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6.

Authors: David Yen; Jeanne Cheung; Heleen Scheerens; Frédérique Poulet; Terrill McClanahan; Brent McKenzie; Melanie A Kleinschek; Alex Owyang; Jeanine Mattson; Wendy Blumenschein; Erin Murphy; Manjiri Sathe; Daniel J Cua; Robert A Kastelein; Donna Rennick
Journal: J Clin Invest Date: 2006-05 Impact factor: 14.808

9. Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis.

Authors: Yi Chen; Claire L Langrish; Brent McKenzie; Barbara Joyce-Shaikh; Jason S Stumhofer; Terrill McClanahan; Wendy Blumenschein; Tatyana Churakovsa; Justin Low; Leonard Presta; Christopher A Hunter; Robert A Kastelein; Daniel J Cua
Journal: J Clin Invest Date: 2006-05 Impact factor: 14.808

10. Intestinal helminths protect in a murine model of asthma.

Authors: Kunihiko Kitagaki; Thomas R Businga; Doina Racila; David E Elliott; Joel V Weinstock; Joel N Kline
Journal: J Immunol Date: 2006-08-01 Impact factor: 5.422

30 in total

1. Effects of appendectomy and oral tolerance on dextran sulfate sodium colitis.

Authors: Min Yue; Zhe Shen; Chao-Hui Yu; Hua Ye; Yue-Fang Ye; You-Ming Li
Journal: World J Gastroenterol Date: 2011-05-21 Impact factor: 5.742

2. Intrinsic requirement for the vitamin D receptor in the development of CD8αα-expressing T cells.

Authors: Danny Bruce; Margherita T Cantorna
Journal: J Immunol Date: 2011-01-26 Impact factor: 5.422

3. Comparative proteomics analysis of serum proteins in ulcerative colitis patients.

Authors: Nan Li; Xueming Wang; Yuefan Zhang; Junshan Zhai; Tuo Zhang; Kaihua Wei
Journal: Mol Biol Rep Date: 2011-12-24 Impact factor: 2.316

Review 4. Familial aggregation in inflammatory bowel disease: is it genes or environment?

Authors: Tiago Nunes; Gionata Fiorino; Silvio Danese; Miquel Sans
Journal: World J Gastroenterol Date: 2011-06-14 Impact factor: 5.742

5. Functional changes in regulatory T cells during an experimental infection with sparganum (plerocercofid of Spirometra mansoni).

Authors: Hyung-Ran Kim; Su-Min Lee; Jong-Wha Won; Woosung Lim; Byung-In Moon; Hyun-Jong Yang; Ju-Young Seoh
Journal: Immunology Date: 2013-01 Impact factor: 7.397

6. The Endoplasmic Reticulum Stress Sensor IRE1α in Intestinal Epithelial Cells Is Essential for Protecting against Colitis.

Authors: Hai-Sheng Zhang; Ying Chen; Li Fan; Qiu-Lei Xi; Guo-Hao Wu; Xiu-Xiu Li; Tang-Long Yuan; Sheng-Qi He; Yue Yu; Meng-Le Shao; Yang Liu; Chen-Guang Bai; Zhi-Qiang Ling; Min Li; Yong Liu; Jing Fang
Journal: J Biol Chem Date: 2015-04-29 Impact factor: 5.157