| Literature DB >> 19320484 |
Jacob Bart1, Ard J Kolkman, Anna Jo Oosthoek-de Vries, Kaspar Koch, Pieter J Nieuwland, Hans J W G Janssen, Jan P J M van Bentum, Kirsten A M Ampt, Floris P J T Rutjes, Sybren S Wijmenga, Han J G E Gardeniers, Arno P M Kentgens.
Abstract
A microfluidic high-resolution NMR flow probe based on a novel stripline detector chip is demonstrated. This tool is invaluable for the in situ monitoring of reactions performed in microreactors. As an example, the acetylation of benzyl alcohol with acetyl chloride was monitored. Because of the uncompromised (sub-Hz) resolution, this probe holds great promise for metabolomics studies, as shown by an analysis of 600 nL of human cerebrospinal fluid.Entities:
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Year: 2009 PMID： 19320484 DOI： 10.1021/ja900389x
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419