OBJECTIVES: A meta-analysis of observational studies on association between cigarette smoking and pancreatic cancer was performed to focus, particularly, on the role of the studies' quality in affecting meta-analysis results. METHODS: A bibliographic search was carried out on PubMed and EMBASE databases until February 15, 2008. Key words were "pancreatic neoplasms," "pancreatic cancer," "smoking," "smoke," "cigarette," "case-control studies," and "cohort studies." Studies about cigarette smoking and pancreatic cancer were selected and assessed on quality. STATA 9.0 was used. RESULTS: Six cohort studies and 24 case-control studies were selected, with median quality scores of 8 (range, 3) and 10 (range, 8), respectively. Pooled case-control studies' odds ratio (OR) and cohort studies' risk ratio were, respectively, 1.45 (95% confidence interval [CI], 1.33-1.57) and 1.78 (95% CI, 1.64-1.92). After stratifying for quality scoring, high-quality-scored case-control studies yielded an OR of 1.38 (95% CI, 1.27-1.49), whereas the others gave an OR of 1.52 (95% CI, 1.34-1.73). The results of meta-analysis for cohort studies showed a risk ratio of 1.74 (95% CI, 1.61-1.90) and of 2.10 (95% CI, 1.64-2.67), respectively, for high- and low-quality score studies. CONCLUSIONS: There is evidence that cigarette smoking is an important risk factor for pancreatic cancer, but the estimate of the association greatly relies on the studies' quality.
OBJECTIVES: A meta-analysis of observational studies on association between cigarette smoking and pancreatic cancer was performed to focus, particularly, on the role of the studies' quality in affecting meta-analysis results. METHODS: A bibliographic search was carried out on PubMed and EMBASE databases until February 15, 2008. Key words were "pancreatic neoplasms," "pancreatic cancer," "smoking," "smoke," "cigarette," "case-control studies," and "cohort studies." Studies about cigarette smoking and pancreatic cancer were selected and assessed on quality. STATA 9.0 was used. RESULTS: Six cohort studies and 24 case-control studies were selected, with median quality scores of 8 (range, 3) and 10 (range, 8), respectively. Pooled case-control studies' odds ratio (OR) and cohort studies' risk ratio were, respectively, 1.45 (95% confidence interval [CI], 1.33-1.57) and 1.78 (95% CI, 1.64-1.92). After stratifying for quality scoring, high-quality-scored case-control studies yielded an OR of 1.38 (95% CI, 1.27-1.49), whereas the others gave an OR of 1.52 (95% CI, 1.34-1.73). The results of meta-analysis for cohort studies showed a risk ratio of 1.74 (95% CI, 1.61-1.90) and of 2.10 (95% CI, 1.64-2.67), respectively, for high- and low-quality score studies. CONCLUSIONS: There is evidence that cigarette smoking is an important risk factor for pancreatic cancer, but the estimate of the association greatly relies on the studies' quality.
Authors: Lauren E McCullough; Maret L Maliniak; Avnika B Amin; Julia M Baker; Davit Baliashvili; Julie Barberio; Chloe M Barrera; Carolyn A Brown; Lindsay J Collin; Alexa A Freedman; David C Gibbs; Maryam B Haddad; Eric W Hall; Sarah Hamid; Kristin R V Harrington; Aaron M Holleman; John A Kaufman; Mohammed A Khan; Katie Labgold; Veronica C Lee; Amyn A Malik; Laura M Mann; Kristin J Marks; Kristin N Nelson; Zerleen S Quader; Katherine Ross-Driscoll; Supriya Sarkar; Monica P Shah; Iris Y Shao; Jonathan P Smith; Kaitlyn K Stanhope; Marisol Valenzuela-Lara; Miriam E Van Dyke; Kartavya J Vyas; Timothy L Lash Journal: Sci Adv Date: 2022-06-08 Impact factor: 14.957
Authors: Giuseppe La Torre; Antonella Sferrazza; Maria Rosaria Gualano; Chiara de Waure; Gennaro Clemente; Agostino Maria De Rose; Nicola Nicolotti; Gennaro Nuzzo; Roberta Siliquini; Antonio Boccia; Walter Ricciardi Journal: Biomed Res Int Date: 2014-04-29 Impact factor: 3.411