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Literature DB >> 19307364

Intracellular localization of the ABCC proteins of Leishmania and their role in resistance to antimonials.

Philippe Leprohon¹, Danielle Légaré, Marc Ouellette.

Abstract

The ABCC subfamily of proteins is composed of nine members in Leishmania. We report that all of these proteins have an intracellular localization and that the overexpression of at least four members, ABCC3, ABCC4, ABCC5, and ABCC7, can confer resistance to antimonials, the first-line drug against Leishmania.

Entities: Disease Gene

Mesh：

Substances：

Year: 2009 PMID： 19307364 PMCID： PMC2687239 DOI： 10.1128/AAC.01474-08

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

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