Literature DB >> 19306914

A new dicoumarin and anticoagulant activity from Viola yedoensis Makino.

Hai Yan Zhou1, Jun Li Hong, Pan Shu, Yue Juan Ni, Min Jian Qin.   

Abstract

A new dicoumarin, named as dimeresculetin (1), together with another dicoumarin, euphorbetin (2) and esculetin (3) were isolated from the ethyl acetate extract of the dried whole plants of Viola yedoensis Makino. The structure of 1 was elucidated as 7-hydroxy-6-[(6,7-dihydroxy-2-oxo-2H-1-benzopyran-5-yl)oxy]-2H-1-benzopyran-2-one on the basis of extensive NMR, as well as the other spectral analysis. Compounds 1-3 exhibited anticoagulant activities with respect to activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT).

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Year:  2009        PMID： 19306914     DOI： 10.1016/j.fitote.2009.03.005

Source DB:  PubMed          Journal:  Fitoterapia        ISSN： 0367-326X            Impact factor:   2.882


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