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Literature DB >> 19306898

Syk and pTyr'd: Signaling through the B cell antigen receptor.

Abstract

The B cell receptor (BCR) transduces antigen binding into alterations in the activity of intracellular signaling pathways through its ability to recruit and activate the cytoplasmic protein-tyrosine kinase Syk. The recruitment of Syk to the receptor, its activation and its subsequent interactions with downstream effectors are all regulated by its phosphorylation on tyrosine. This review discusses our current understanding of how this phosphorylation regulates the activity of Syk and its participation in signaling through the BCR.

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Year: 2009 PMID： 19306898 PMCID： PMC2700185 DOI： 10.1016/j.bbamcr.2009.03.004

Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002

216 in total

Review 1. Regulation of B-cell signal transduction by adaptor proteins.

Authors: Tomohiro Kurosaki
Journal: Nat Rev Immunol Date: 2002-05 Impact factor: 53.106

2. Proteasome-dependent regulation of Syk tyrosine kinase levels in human basophils.

Authors: Lama A Youssef; Bridget S Wilson; Janet M Oliver
Journal: J Allergy Clin Immunol Date: 2002-09 Impact factor: 10.793

3. The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways.

Authors: Shara Kabak; Brian J Skaggs; Michael R Gold; Michael Affolter; Kelly L West; Mark S Foster; Karyn Siemasko; Andrew C Chan; Ruedi Aebersold; Marcus R Clark
Journal: Mol Cell Biol Date: 2002-04 Impact factor: 4.272

4. Phosphorylation of Tyr342 in the linker region of Syk is critical for Fc epsilon RI signaling in mast cells.

Authors: Juan Zhang; Elsa Berenstein; Reuben P Siraganian
Journal: Mol Cell Biol Date: 2002-12 Impact factor: 4.272

5. A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling.

Authors: Hadassa Waterman; Menachem Katz; Chanan Rubin; Keren Shtiegman; Sara Lavi; Ari Elson; Thomas Jovin; Yosef Yarden
Journal: EMBO J Date: 2002-02-01 Impact factor: 11.598

6. Multiple phosphorylation of alpha-synuclein by protein tyrosine kinase Syk prevents eosin-induced aggregation.

Authors: Alessandro Negro; Anna Maria Brunati; Arianna Donella-Deana; Maria Lina Massimino; Lorenzo A Pinna
Journal: FASEB J Date: 2001-12-14 Impact factor: 5.191

7. ITAM-based interaction of ERM proteins with Syk mediates signaling by the leukocyte adhesion receptor PSGL-1.

Authors: Ana Urzainqui; Juan M Serrador; Fernando Viedma; María Yáñez-Mó; Antonio Rodríguez; Angel L Corbí; Jose L Alonso-Lebrero; Alfonso Luque; Marcel Deckert; Jesús Vázquez; Francisco Sánchez-Madrid
Journal: Immunity Date: 2002-10 Impact factor: 31.745

8. Activation of ZAP-70 through specific dephosphorylation at the inhibitory Tyr-292 by the low molecular weight phosphotyrosine phosphatase (LMPTP).

Authors: Nunzio Bottini; Lavinia Stefanini; Scott Williams; Andres Alonso; Thomas Jascur; Robert T Abraham; Clement Couture; Tomas Mustelin
Journal: J Biol Chem Date: 2002-04-25 Impact factor: 5.157

9. Activation of Syk tyrosine kinase is required for c-Cbl-mediated ubiquitination of Fcepsilon RI and Syk in RBL cells.

Authors: Rossella Paolini; Rosa Molfetta; Laurie O Beitz; Juan Zhang; Andrew M Scharenberg; Mario Piccoli; Luigi Frati; Reuben Siraganian; Angela Santoni
Journal: J Biol Chem Date: 2002-07-26 Impact factor: 5.157

10. Regulation of signaling in B cells through the phosphorylation of Syk on linker region tyrosines. A mechanism for negative signaling by the Lyn tyrosine kinase.

Authors: Julie J Hong; Thomas M Yankee; Marietta L Harrison; Robert L Geahlen
Journal: J Biol Chem Date: 2002-06-20 Impact factor: 5.157

74 in total

1. The cytokine midkine and its receptor RPTPζ regulate B cell survival in a pathway induced by CD74.

Authors: Sivan Cohen; Or-yam Shoshana; Einat Zelman-Toister; Nitsan Maharshak; Inbal Binsky-Ehrenreich; Maya Gordin; Inbal Hazan-Halevy; Yair Herishanu; Lev Shvidel; Michal Haran; Lin Leng; Richard Bucala; Sheila Harroch; Idit Shachar
Journal: J Immunol Date: 2011-12-02 Impact factor: 5.422

2. Sensitive kinase assay linked with phosphoproteomics for identifying direct kinase substrates.

Authors: Liang Xue; Wen-Horng Wang; Anton Iliuk; Lianghai Hu; Jacob A Galan; Shuai Yu; Michael Hans; Robert L Geahlen; W Andy Tao
Journal: Proc Natl Acad Sci U S A Date: 2012-03-26 Impact factor: 11.205

3. Identification of direct tyrosine kinase substrates based on protein kinase assay-linked phosphoproteomics.

Authors: Liang Xue; Robert L Geahlen; W Andy Tao
Journal: Mol Cell Proteomics Date: 2013-06-22 Impact factor: 5.911

4. TC21/RRas2 regulates glycoprotein VI-FcRγ-mediated platelet activation and thrombus stability.

Authors: S Janapati; J Wurtzel; C Dangelmaier; B K Manne; D Bhavanasi; J C Kostyak; S Kim; M Holinstat; S P Kunapuli; L E Goldfinger
Journal: J Thromb Haemost Date: 2018-06-08 Impact factor: 5.824

5. The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2.

Authors: Kyung D Moon; Xiaoying Zhang; Qing Zhou; Robert L Geahlen
Journal: Biochim Biophys Acta Date: 2011-10-12

6. Entropic allostery dominates the phosphorylation-dependent regulation of Syk tyrosine kinase release from immunoreceptor tyrosine-based activation motifs.

Authors: Chao Feng; Amitava Roy; Carol Beth Post
Journal: Protein Sci Date: 2018-10-02 Impact factor: 6.725