Literature DB >> 19306875

Beta2-chimaerin binds to EphA receptors and regulates cell migration.

Shingo Takeuchi1, Nao Yamaki, Takuji Iwasato, Manabu Negishi, Hironori Katoh.   

Abstract

Ephrins and Eph receptors have key roles in regulation of cell migration during development. We found that the RacGAP beta2-chimaerin (chimerin) bound to EphA2 and EphA4 and inactivated Rac1 in response to ephrinA1 stimulation. EphA4 bound to beta2-chimaerin through its kinase domain and promoted binding of Rac1 to beta2-chimaerin. In addition, knockdown of endogenous beta2-chimaerin blocked ephrinA1-induced suppression of cell migration. These results suggest that beta2-chimaerin is activated by EphA receptors and mediates the EphA receptor-dependent regulation of cell migration.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19306875     DOI： 10.1016/j.febslet.2009.03.032

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  13 in total

Review 1.  Eph receptors and ephrins in cancer: bidirectional signalling and beyond.

Authors:  Elena B Pasquale
Journal:  Nat Rev Cancer       Date:  2010-03       Impact factor: 60.716

2.  Identification of a truncated β1-chimaerin variant that inactivates nuclear Rac1.

Authors:  Victoria Casado-Medrano; Laura Barrio-Real; Laura Gutiérrez-Miranda; Rogelio González-Sarmiento; Eladio A Velasco; Marcelo G Kazanietz; María J Caloca
Journal:  J Biol Chem       Date:  2019-12-22       Impact factor: 5.157

3.  Rac GTPase-activating protein (Rac GAP) α1-Chimaerin undergoes proteasomal degradation and is stabilized by diacylglycerol signaling in neurons.

Authors:  Jamie R K Marland; DingXin Pan; Philip C Buttery
Journal:  J Biol Chem       Date:  2010-11-05       Impact factor: 5.157

Review 4.  Eph-dependent cell-cell adhesion and segregation in development and cancer.

Authors:  Eva Nievergall; Martin Lackmann; Peter W Janes
Journal:  Cell Mol Life Sci       Date:  2011-12-28       Impact factor: 9.261

Review 5.  EphA receptor signaling--complexity and emerging themes.

Authors:  Hui Miao; Bingcheng Wang
Journal:  Semin Cell Dev Biol       Date:  2011-10-21       Impact factor: 7.727

6.  MicroRNA-335 suppresses the proliferation, migration, and invasion of breast cancer cells by targeting EphA4.

Authors:  Yilong Dong; Yang Liu; Aimei Jiang; Ruiqian Li; Min Yin; Yanmei Wang
Journal:  Mol Cell Biochem       Date:  2017-08-09       Impact factor: 3.396

7.  Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism.

Authors:  Nao Hiramoto-Yamaki; Shingo Takeuchi; Shuhei Ueda; Kohei Harada; Satoshi Fujimoto; Manabu Negishi; Hironori Katoh
Journal:  J Cell Biol       Date:  2010-08-02       Impact factor: 10.539

8.  Biochemical characterization of hyperactive beta2-chimaerin mutants revealed an enhanced exposure of C1 and Rac-GAP domains.

Authors:  Maria Soledad Sosa; Nancy E Lewin; Sung-Hee Choi; Peter M Blumberg; Marcelo G Kazanietz
Journal:  Biochemistry       Date:  2009-09-01       Impact factor: 3.162

9.  The EphA4 Signaling is Anti-catabolic in Synoviocytes but Pro-anabolic in Articular Chondrocytes.

Authors:  Virginia M Stiffel; Alexander Thomas; Charles H Rundle; Matilda H-C Sheng; Kin-Hing William Lau
Journal:  Calcif Tissue Int       Date:  2020-08-20       Impact factor: 4.333

10.  A maximum likelihood QTL analysis reveals common genome regions controlling resistance to Salmonella colonization and carrier-state.

Authors:  Tran Thanh-Son; Beaumont Catherine; Salmon Nigel; Fife Mark; Kaiser Pete; Le Bihan-Duval Elisabeth; Vignal Alain; Velge Philippe; Calenge Fanny
Journal:  BMC Genomics       Date:  2012-05-21       Impact factor: 3.969
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.