AIM: To identify biomarkers for diagnosis and prognosis of hepatocellular carcinoma (HCC). METHODS: Screening the HCC cDNA library with HCC patients sera. Isolated proteins were used as antigens to detect antibodies from patients with HCC and control sera. RESULTS: Eighty-one positive clones were identified. The frequencies of autoantibody against five HCC-associated antigens were higher in HCC than that in chronic hepatitis and normal human sera. The sensitivity and specificity of KRT23, AHSG and FTL antigens combination tests up to 98.2% in joint test and 90.0% in series test separately. CONCLUSIONS: HCC associate antigens identified from this study supply candidate markers of diagnosis, combined detection and immunotherapy of HCC.
AIM: To identify biomarkers for diagnosis and prognosis of hepatocellular carcinoma (HCC). METHODS: Screening the HCC cDNA library with HCC patients sera. Isolated proteins were used as antigens to detect antibodies from patients with HCC and control sera. RESULTS: Eighty-one positive clones were identified. The frequencies of autoantibody against five HCC-associated antigens were higher in HCC than that in chronic hepatitis and normal human sera. The sensitivity and specificity of KRT23, AHSG and FTL antigens combination tests up to 98.2% in joint test and 90.0% in series test separately. CONCLUSIONS: HCC associate antigens identified from this study supply candidate markers of diagnosis, combined detection and immunotherapy of HCC.
Authors: Tan Zhang; Xin Feng; Juan Dong; Zherong Xu; Bo Feng; Karen M Haas; Peggy M Cawthon; Kristen M Beavers; Barbara Nicklas; Stephen Kritchevsky Journal: Geroscience Date: 2022-01-15 Impact factor: 7.581
Authors: Julia Starmann; Maria Fälth; Walter Spindelböck; Katja-Lauren Lanz; Carolin Lackner; Kurt Zatloukal; Michael Trauner; Holger Sültmann Journal: PLoS One Date: 2012-10-10 Impact factor: 3.240