| Literature DB >> 1930333 |
F de Benedetti1, M Massa, P Robbioni, A Ravelli, G R Burgio, A Martini.
Abstract
We measured interleukin-6 (IL-6) levels in 70 serum samples obtained from 25 patients with systemic-onset juvenile rheumatoid arthritis (JRA), using the hybridoma cell line B9. Patients with systemic-onset JRA had significantly elevated serum IL-6 levels during active disease (mean +/- SD 92.1 +/- 75.1 hybridoma growth factor units/ml; P less than 0.00001 versus healthy age-matched controls), but not during remission. Serum IL-6 levels correlated with the extent and severity of joint involvement (P less than 0.001) and with platelet counts (P less than 0.05). Our data suggest that IL-6 plays a significant role in the pathogenesis of systemic-onset JRA.Entities:
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Year: 1991 PMID： 1930333 DOI： 10.1002/art.1780340912
Source DB: PubMed Journal: Arthritis Rheum ISSN： 0004-3591