| Literature DB >> 19303291 |
Fateh V Singh1, Amrita Parihar, Sumit Chaurasia, Amar B Singh, Salil P Singh, Akhilesh K Tamrakar, Arvind K Srivastava, Atul Goel.
Abstract
Various functionalized mono- and diarylanthranilo-1,3-dinitriles were synthesized and evaluated for their in vitro antihyperglycemic activity against the PTP-1B, glucose-6-phosphatase, glycogen phosphorylase and alpha-glucosidase enzymes. Among various screened compounds, 5,6-diaryl substituted anthranilo-1,3-dinitriles 3a, 3b, and 3d showed good inhibitory activity against PTP-1B with IC(50) values of 58-72 microM. Three of the test compounds showed significant (25-37%) lowering of plasma glucose level at 24h in sucrose-challenged streptozotocin-induced diabetic Sprague-Dawley rat model.Entities:
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Year: 2009 PMID： 19303291 DOI： 10.1016/j.bmcl.2009.02.118
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823