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Literature DB >> 19302999

Common genetic variants of the vitamin D binding protein (DBP) predict differences in response of serum 25-hydroxyvitamin D [25(OH)D] to vitamin D supplementation.

Lei Fu¹, Francisco Yun, Marko Oczak, Betty Y L Wong, Reinhold Vieth, David E C Cole.

Abstract

BACKGROUND: To determine the effect of vitamin D binding protein (DBP) genotypes on 25-hydroxyvitamin D [25(OH)D] changes with vitamin D supplements, we studied 98 adults receiving 600 or 4000 IU/d vitamin D(3) for one year.
METHODS: The DBP functional variant, T436K, was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
RESULTS: Mean 25(OH)D increases were 97% for TT (n=48), 151% for TK (n=31) and 307% (n=6) for KK genotypes (p=.004).
CONCLUSIONS: As with baseline 25(OH)D, T436K genotype predicts 25(OH)D changes after long-term vitamin D supplementation.

Entities: Chemical Gene Mutation

Mesh：

Substances：

Year: 2009 PMID： 19302999 DOI： 10.1016/j.clinbiochem.2009.03.008

Source DB: PubMed Journal: Clin Biochem ISSN： 0009-9120 Impact factor: 3.281

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Cited

75 in total

1. Vitamin D deficiency is prevalent in girls and women with Rett syndrome.

Authors: Kathleen J Motil; Judy O Barrish; Jane Lane; Suzanne P Geerts; Fran Annese; Lauren McNair; Alan K Percy; Steven A Skinner; Jeffrey L Neul; Daniel G Glaze
Journal: J Pediatr Gastroenterol Nutr Date: 2011-11 Impact factor: 2.839

2. Polymorphic variation in the GC and CASR genes and associations with vitamin D metabolite concentration and metachronous colorectal neoplasia.

Authors: Elizabeth A Hibler; Chengcheng Hu; Peter W Jurutka; Maria E Martinez; Elizabeth T Jacobs
Journal: Cancer Epidemiol Biomarkers Prev Date: 2011-12-05 Impact factor: 4.254

10. Vitamin D status of black and white Americans and changes in vitamin D metabolites after varied doses of vitamin D supplementation.

Authors: Naweed S Alzaman; Bess Dawson-Hughes; Jason Nelson; David D'Alessio; Anastassios G Pittas
Journal: Am J Clin Nutr Date: 2016-05-18 Impact factor: 7.045

Common genetic variants of the vitamin D binding protein (DBP) predict differences in response of serum 25-hydroxyvitamin D [25(OH)D] to vitamin D supplementation.

1. Vitamin D deficiency is prevalent in girls and women with Rett syndrome.

2. Polymorphic variation in the GC and CASR genes and associations with vitamin D metabolite concentration and metachronous colorectal neoplasia.

3. Associations between common variants in GC and DHCR7/NADSYN1 and vitamin D concentration in Chinese Hans.

4. Blood vitamin d levels in relation to genetic estimation of African ancestry.

Review 5. Variability in free 25(OH) vitamin D levels in clinical populations.

Review 6. Factors influencing the absorption of vitamin D in GIT: an overview.

7. Type of dietary fat is associated with the 25-hydroxyvitamin D3 increment in response to vitamin D supplementation.

8. Determinants of serum 25 hydroxyvitamin D levels in a nationwide cohort of blacks and non-Hispanic whites.

Review 9. Benefit-risk assessment of vitamin D supplementation.

10. Vitamin D status of black and white Americans and changes in vitamin D metabolites after varied doses of vitamin D supplementation.