Literature DB >> 19301344

Iterative in situ click chemistry creates antibody-like protein-capture agents.

Heather D Agnew1, Rosemary D Rohde, Steven W Millward, Arundhati Nag, Woon-Seok Yeo, Jason E Hein, Suresh M Pitram, Abdul Ahad Tariq, Vanessa M Burns, Russell J Krom, Valery V Fokin, K Barry Sharpless, James R Heath.   

Abstract

Special agents for protein capture: Iterative in situ click chemistry (see scheme for the tertiary ligand screen) and the one-bead-one-compound method for the creation of a peptide library enable the fragment-based assembly of selective high-affinity protein-capture agents. The resulting ligands are water-soluble and stable chemically, biochemically, and thermally. They can be produced in gram quantities through copper(I)-catalyzed cycloaddition.

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Year:  2009        PMID： 19301344      PMCID： PMC3716464          DOI： 10.1002/anie.200900488

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  22 in total

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Review 6.  Aptamers--basic research, drug development, and clinical applications.

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10.  Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation.

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  46 in total

1.  Grand challenge commentary: Informative diagnostics for personalized medicine.

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Journal:  Nat Chem Biol       Date:  2010-12       Impact factor: 15.040

2.  A General Synthetic Approach for Designing Epitope Targeted Macrocyclic Peptide Ligands.

Authors:  Samir Das; Arundhati Nag; JingXin Liang; David N Bunck; Aiko Umeda; Blake Farrow; Matthew B Coppock; Deborah A Sarkes; Amethist S Finch; Heather D Agnew; Suresh Pitram; Bert Lai; Mary Beth Yu; A Katrine Museth; Kaycie M Deyle; Bianca Lepe; Frances P Rodriguez-Rivera; Amy McCarthy; Belen Alvarez-Villalonga; Ann Chen; John Heath; Dimitra N Stratis-Cullum; James R Heath
Journal:  Angew Chem Int Ed Engl       Date:  2015-09-17       Impact factor: 15.336

3.  Exploitation of the Ornithine Effect Enhances Characterization of Stapled and Cyclic Peptides.

Authors:  Christopher M Crittenden; W Ryan Parker; Zachary B Jenner; Kerry A Bruns; Lucas D Akin; William M McGee; Eugene Ciccimaro; Jennifer S Brodbelt
Journal:  J Am Soc Mass Spectrom       Date:  2016-02-10       Impact factor: 3.109

4.  Identification of selective covalent inhibitors of platelet activating factor acetylhydrolase 1B2 from the screening of an oxadiazolone-capped peptoid-azapeptoid hybrid library.

Authors:  Bani Kanta Sarma; Xiaodan Liu; Thomas Kodadek
Journal:  Bioorg Med Chem       Date:  2016-04-23       Impact factor: 3.641

5.  Protein binding: Antibody surrogates click into place.

Authors:  Thomas Kodadek
Journal:  Nat Chem       Date:  2009-06       Impact factor: 24.427

Review 6.  Synthetic receptors with antibody-like binding affinities.

Authors:  Thomas Kodadek
Journal:  Curr Opin Chem Biol       Date:  2010-07-30       Impact factor: 8.822

Review 7.  Protein-Catalyzed Capture Agents.

Authors:  Heather D Agnew; Matthew B Coppock; Matthew N Idso; Bert T Lai; JingXin Liang; Amy M McCarthy-Torrens; Carmen M Warren; James R Heath
Journal:  Chem Rev       Date:  2019-03-06       Impact factor: 60.622

Review 8.  Turning single cells into microarrays by super-resolution barcoding.

Authors:  Long Cai
Journal:  Brief Funct Genomics       Date:  2012-11-22       Impact factor: 4.241

Review 9.  Approaches to Validate and Manipulate RNA Targets with Small Molecules in Cells.

Authors:  Jessica L Childs-Disney; Matthew D Disney
Journal:  Annu Rev Pharmacol Toxicol       Date:  2015-10-22       Impact factor: 13.820

Review 10.  Aptamers and the next generation of diagnostic reagents.

Authors:  Varatharasa Thiviyanathan; David G Gorenstein
Journal:  Proteomics Clin Appl       Date:  2012-12       Impact factor: 3.494
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