Literature DB >> 19299327

The LDL receptor.

Joseph L Goldstein1, Michael S Brown.   

Abstract

In this article, the history of the LDL receptor is recounted by its codiscoverers. Their early work on the LDL receptor explained a genetic cause of heart attacks and led to new ways of thinking about cholesterol metabolism. The LDL receptor discovery also introduced three general concepts to cell biology: receptor-mediated endocytosis, receptor recycling, and feedback regulation of receptors. The latter concept provides the mechanism by which statins selectively lower plasma LDL, reducing heart attacks and prolonging life.

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Year:  2009        PMID： 19299327      PMCID： PMC2740366          DOI： 10.1161/ATVBAHA.108.179564

Source DB:  PubMed          Journal:  Arterioscler Thromb Vasc Biol        ISSN： 1079-5642            Impact factor:   8.311


  52 in total

Review 1.  SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver.

Authors:  Jay D Horton; Joseph L Goldstein; Michael S Brown
Journal:  J Clin Invest       Date:  2002-05       Impact factor: 14.808

Review 2.  Lipoprotein receptors in the nervous system.

Authors:  Joachim Herz; Hans H Bock
Journal:  Annu Rev Biochem       Date:  2001-11-09       Impact factor: 23.643

Review 3.  Niemann-Pick C research from mouse to gene.

Authors:  Peter G Pentchev
Journal:  Biochim Biophys Acta       Date:  2004-10-11

4.  Effect of statins on risk of coronary disease: a meta-analysis of randomized controlled trials.

Authors:  J C LaRosa; J He; S Vupputuri
Journal:  JAMA       Date:  1999 Dec 22-29       Impact factor: 56.272

Review 5.  Lipid metabolism in tissue culture cells.

Authors:  G H Rothblat
Journal:  Adv Lipid Res       Date:  1969

6.  Genetic evidence for nonredundant functional cooperativity between NPC1 and NPC2 in lipid transport.

Authors:  David E Sleat; Jennifer A Wiseman; Mukarram El-Banna; Sandy M Price; Lucie Verot; Michael M Shen; G Stephen Tint; Marie T Vanier; Steven U Walkley; Peter Lobel
Journal:  Proc Natl Acad Sci U S A       Date:  2004-04-07       Impact factor: 11.205

7.  Familial hypercholesterolemia: identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol.

Authors:  J L Goldstein; M S Brown
Journal:  Proc Natl Acad Sci U S A       Date:  1973-10       Impact factor: 11.205

8.  Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts by lipoproteins.

Authors:  M S Brown; S E Dana; J L Goldstein
Journal:  Proc Natl Acad Sci U S A       Date:  1973-07       Impact factor: 11.205

9.  Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme.

Authors:  G Gil; J R Faust; D J Chin; J L Goldstein; M S Brown
Journal:  Cell       Date:  1985-05       Impact factor: 41.582

10.  Binding between the Niemann-Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domain.

Authors:  Nobutaka Ohgami; Dennis C Ko; Matthew Thomas; Matthew P Scott; Catherine C Y Chang; Ta-Yuan Chang
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-16       Impact factor: 11.205
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  380 in total

1.  Autosomal recessive hypercholesterolaemia in a Morrocan family due to a mutation of the G266C LDL receptor.

Authors:  Siham El Aziz; Asma Chadli; Hassan El Ghomari; Ahmed Farouqi
Journal:  BMJ Case Rep       Date:  2012-05-23

Review 2.  Lipid Metabolism in Tumor-Associated Macrophages.

Authors:  Yuancai Xiang; Hongming Miao
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

3.  Association between serum soluble low-density lipoprotein receptor levels and metabolic factors in healthy Japanese individuals.

Authors:  Hisashi Shimohiro; Shin-Ichi Taniguchi; Masahiko Koda; Chieko Sakai; Sadako Yamada
Journal:  J Clin Lab Anal       Date:  2014-03-28       Impact factor: 2.352

4.  Lack of a relationship between plasma PCSK9 concentrations and hepatic lipoprotein kinetics in obese people.

Authors:  Shelby Sullivan; Elisa Fabbrini; Jay D Horton; Kevin Korenblat; Bruce W Patterson; Samuel Klein
Journal:  Transl Res       Date:  2011-07-19       Impact factor: 7.012

5.  Hypercholesterolemia and ApoE deficiency result in severe infection with Lyme disease and relapsing-fever Borrelia.

Authors:  Alvaro Toledo; Javier D Monzón; James L Coleman; Juan C Garcia-Monco; Jorge L Benach
Journal:  Proc Natl Acad Sci U S A       Date:  2015-04-13       Impact factor: 11.205

6.  MicroRNA-27a decreases the level and efficiency of the LDL receptor and contributes to the dysregulation of cholesterol homeostasis.

Authors:  M Lucrecia Alvarez; Mahdieh Khosroheidari; Elena Eddy; Stefania C Done
Journal:  Atherosclerosis       Date:  2015-08-20       Impact factor: 5.162

7.  Cerebrovascular Angiogenic Reprogramming upon LRP1 Repression: Impact on Sphingosine-1-Phosphate-Mediated Signaling in Brain Endothelial Cell Chemotactism.

Authors:  Amélie Vézina; Cyndia Charfi; Alain Zgheib; Borhane Annabi
Journal:  Mol Neurobiol       Date:  2017-05-17       Impact factor: 5.590

Review 8.  Cholesterol metabolism in cholestatic liver disease and liver transplantation: From molecular mechanisms to clinical implications.

Authors:  Katriina Nemes; Fredrik Åberg; Helena Gylling; Helena Isoniemi
Journal:  World J Hepatol       Date:  2016-08-08

Review 9.  Targeting the β secretase BACE1 for Alzheimer's disease therapy.

Authors:  Riqiang Yan; Robert Vassar
Journal:  Lancet Neurol       Date:  2014-02-17       Impact factor: 44.182

10.  LDL receptor and its family members serve as the cellular receptors for vesicular stomatitis virus.

Authors:  Danit Finkelshtein; Ariel Werman; Daniela Novick; Sara Barak; Menachem Rubinstein
Journal:  Proc Natl Acad Sci U S A       Date:  2013-04-15       Impact factor: 11.205
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