BACKGROUND: Interleukin 16 (IL-16) is an immunomodulatory cytokine which plays an important role in many inflammatory and autoimmune diseases. We determined the association between SNPs of IL-16 gene (i.e. rs11556218 G/T, rs4778889 C/T, and rs4072111 C/T) and systemic lupus erythematosus (SLE). METHODS: One hundred thirty-eight SLE patients and 199 controls were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing assay. RESULTS: In the SLE group, the individuals carrying the G allele of rs11556218, the C allele of rs4778889 and the T allele of rs4072111 are at a significantly higher risk of SLE as compared with those carrying the T allele of rs11556218, the T allele of rs4778889, and the C allele of rs4072111 respectively (for rs11556218, OR=2.264, 95% CI, 1.64-3.127; for rs4778889, OR=1.927, 95%CI, 1.359-2.731; and for rs4072111, OR=2.417, 95% CI, 1.691-3.455). CONCLUSIONS: The IL-16 gene polymorphisms may be associated with the risk of SLE.
BACKGROUND:Interleukin 16 (IL-16) is an immunomodulatory cytokine which plays an important role in many inflammatory and autoimmune diseases. We determined the association between SNPs of IL-16 gene (i.e. rs11556218 G/T, rs4778889 C/T, and rs4072111 C/T) and systemic lupus erythematosus (SLE). METHODS: One hundred thirty-eight SLEpatients and 199 controls were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing assay. RESULTS: In the SLE group, the individuals carrying the G allele of rs11556218, the C allele of rs4778889 and the T allele of rs4072111 are at a significantly higher risk of SLE as compared with those carrying the T allele of rs11556218, the T allele of rs4778889, and the C allele of rs4072111 respectively (for rs11556218, OR=2.264, 95% CI, 1.64-3.127; for rs4778889, OR=1.927, 95%CI, 1.359-2.731; and for rs4072111, OR=2.417, 95% CI, 1.691-3.455). CONCLUSIONS: The IL-16 gene polymorphisms may be associated with the risk of SLE.
Authors: Andrea Fava; Deepak A Rao; Chandra Mohan; Ting Zhang; Avi Rosenberg; Paride Fenaroli; H Michael Belmont; Peter Izmirly; Robert Clancy; Jose Monroy Trujillo; Derek Fine; Arnon Arazi; Celine C Berthier; Anne Davidson; Judith A James; Betty Diamond; Nir Hacohen; David Wofsy; Soumya Raychaudhuri; William Apruzzese; Jill Buyon; Michelle Petri Journal: Arthritis Rheumatol Date: 2022-04-16 Impact factor: 15.483
Authors: Rachid Abaji; Vincent Gagné; Chang Jiang Xu; Jean-François Spinella; Francesco Ceppi; Caroline Laverdière; Jean-Marie Leclerc; Stephen E Sallan; Donna Neuberg; Jeffery L Kutok; Lewis B Silverman; Daniel Sinnett; Maja Krajinovic Journal: Oncotarget Date: 2017-07-04
Authors: Michail Matalliotakis; Maria I Zervou; Elias Eliopoulos; Charoula Matalliotaki; Nilufer Rahmioglu; Ioannis Kalogiannidis; Krina Zondervan; Demetrios A Spandidos; Ioannis Matalliotakis; George N Goulielmos Journal: Int J Mol Med Date: 2018-01-09 Impact factor: 4.101
Authors: Charoula Matalliotaki; Michail Matalliotakis; Maria I Zervou; Alexandra Trivli; Ioannis Matalliotakis; George Mavromatidis; Demetrios A Spandidos; Hans M Albertsen; Rakesh Chettier; Kenneth Ward; George N Goulielmos Journal: Mol Med Rep Date: 2018-10-01 Impact factor: 2.952