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Literature DB >> 19297193

Isomer separation and gas-phase configurations of organoruthenium anticancer complexes: ion mobility mass spectrometry and modeling.

Jonathan P Williams¹, Tijana Bugarcic, Abraha Habtemariam, Kevin Giles, Iain Campuzano, P Mark Rodger, Peter J Sadler.

Abstract

We have used ion mobility-mass spectrometry combined with molecular modeling for the separation and configurational analysis of three low-molecular-weight isomeric organoruthenium anticancer complexes containing ortho-, meta-, or para-terphenyl arene ligands. The isomers were separated using ion mobility based on traveling-wave technology and the experimentally determined collision cross sections were compared to theoretical calculations. Excellent agreement was observed between the experimentally and theoretically derived measurements.

Entities: Chemical

Mesh：

Substances：

Year: 2009 PMID： 19297193 DOI： 10.1016/j.jasms.2009.02.016

Source DB: PubMed Journal: J Am Soc Mass Spectrom ISSN： 1044-0305 Impact factor: 3.109

9 in total

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Journal: Anal Chem Date: 2000-01-15 Impact factor: 6.986

2. Applications of a travelling wave-based radio-frequency-only stacked ring ion guide.

Authors: Kevin Giles; Steven D Pringle; Kenneth R Worthington; David Little; Jason L Wildgoose; Robert H Bateman
Journal: Rapid Commun Mass Spectrom Date: 2004 Impact factor: 2.419

3. Organometallic ruthenium(II) diamine anticancer complexes: arene-nucleobase stacking and stereospecific hydrogen-bonding in guanine adducts.

Authors: Haimei Chen; John A Parkinson; Simon Parsons; Robert A Coxall; Robert O Gould; Peter J Sadler
Journal: J Am Chem Soc Date: 2002-03-27 Impact factor: 15.419

4. Structural analysis of drug-DNA adducts by tandem mass spectrometry.

Authors: P Iannitti-Tito; A Weimann; G Wickham; M M Sheil
Journal: Analyst Date: 2000-04 Impact factor: 4.616

5. DNA interactions of monofunctional organometallic ruthenium(II) antitumor complexes in cell-free media.

Authors: Olga Novakova; Haimei Chen; Oldrich Vrana; Alison Rodger; Peter J Sadler; Viktor Brabec
Journal: Biochemistry Date: 2003-10-07 Impact factor: 3.162

6. Cytotoxicity, cellular uptake, and DNA interactions of new monodentate ruthenium(II) complexes containing terphenyl arenes.

Authors: Tijana Bugarcic; Olga Nováková; Anna Halámiková; Lenka Zerzánková; Oldrich Vrána; Jana Kaspárková; Abraha Habtemariam; Simon Parsons; Peter J Sadler; Viktor Brabec
Journal: J Med Chem Date: 2008-08-14 Impact factor: 7.446

7. Coupling desorption electrospray ionisation and neutral desorption/extractive electrospray ionisation with a travelling-wave based ion mobility mass spectrometer for the analysis of drugs.

Authors: Jonathan P Williams; James H Scrivens
Journal: Rapid Commun Mass Spectrom Date: 2008 Impact factor: 2.419

8. Rapid resolution of carbohydrate isomers by electrospray ionization ambient pressure ion mobility spectrometry-time-of-flight mass spectrometry (ESI-APIMS-TOFMS).

Authors: Prabha Dwivedi; Brad Bendiak; Brian H Clowers; Herbert H Hill
Journal: J Am Soc Mass Spectrom Date: 2007-04-25 Impact factor: 3.109

Review 9. New trends for metal complexes with anticancer activity.

Authors: Pieter C A Bruijnincx; Peter J Sadler
Journal: Curr Opin Chem Biol Date: 2008-01-25 Impact factor: 8.822

9 in total

17 in total

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Authors: Natalia L Zakharova; Christina L Crawford; Brian C Hauck; Jacob K Quinton; William F Seims; Herbert H Hill; Aurora E Clark
Journal: J Am Soc Mass Spectrom Date: 2012-02-23 Impact factor: 3.109

2. Traveling-wave ion mobility mass spectrometry analysis of isomeric modified peptides arising from chemical cross-linking.

Authors: Luiz F A Santos; Amadeu H Iglesias; Eduardo J Pilau; Alexandre F Gomes; Fabio C Gozzo
Journal: J Am Soc Mass Spectrom Date: 2010-09-21 Impact factor: 3.109

3. Shape changes induced by N-terminal platination of ubiquitin by cisplatin.

Authors: Jonathan P Williams; Hazel I A Phillips; Iain Campuzano; Peter J Sadler
Journal: J Am Soc Mass Spectrom Date: 2010-02-11 Impact factor: 3.109

4. Mass spectrometric strategies to improve the identification of Pt(II)-modification sites on peptides and proteins.

Authors: Huilin Li; Jonathon R Snelling; Mark P Barrow; James H Scrivens; Peter J Sadler; Peter B O'Connor
Journal: J Am Soc Mass Spectrom Date: 2014-05-21 Impact factor: 3.109

5. Integrating ion mobility and imaging mass spectrometry for comprehensive analysis of biological tissues: A brief review and perspective.

Authors: Emilio S Rivera; Katerina V Djambazova; Elizabeth K Neumann; Richard M Caprioli; Jeffrey M Spraggins
Journal: J Mass Spectrom Date: 2020-09-21 Impact factor: 1.982

6. Structural Characterization of Anticancer Drug Paclitaxel and Its Metabolites Using Ion Mobility Mass Spectrometry and Tandem Mass Spectrometry.

Authors: Hong Hee Lee; Areum Hong; Yunju Cho; Sunghwan Kim; Won Jong Kim; Hugh I Kim
Journal: J Am Soc Mass Spectrom Date: 2016-02 Impact factor: 3.109

7. Collision cross-section determination and tandem mass spectrometric analysis of isomeric carotenoids using electrospray ion mobility time-of-flight mass spectrometry.

Authors: Linlin Dong; Henry Shion; Roderick G Davis; Brent Terry-Penak; Jose Castro-Perez; Richard B van Breemen
Journal: Anal Chem Date: 2010-10-07 Impact factor: 6.986