| Literature DB >> 19297023 |
Jurica Arapović1, Tihana Lenac Rovis, Anil Butchi Reddy, Astrid Krmpotić, Stipan Jonjić.
Abstract
Both human and mouse cytomegalovirus (CMV) encode proteins that inhibit the activation of NK cells by down-regulating the cellular ligands for activating NK cell receptor, NKG2D. MCMV proteins m145, m152 and m155 interfere with the expression of all known NKG2D ligands, MULT-1, RAE-1 family members and H60, respectively, whereas m138 affects the expression of MULT-1 and H60. Here we show that m152 affects the maturation of newly synthesized RAE-1 molecules, but is not sufficient to prevent surface expression of RAE-1varepsilon. We have identified m138 as a main inhibitor of the surface expression of RAE-1varepsilon. In contrast to m152, m138 affects the surface-resident protein leading to its endocytosis, which can be prevented by a dynamin inhibitor. Moreover, we demonstrated that m138 does not need other viral proteins to down-modulate the expression of RAE-1varepsilon.Entities:
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Year: 2009 PMID： 19297023 DOI： 10.1016/j.molimm.2009.02.010
Source DB: PubMed Journal: Mol Immunol ISSN： 0161-5890 Impact factor: 4.407