OBJECTIVE: To describe the natural history and risk of early chronic kidney disease (CKD) in Indigenous Australian populations. DESIGN, SETTING AND PARTICIPANTS: A prospective cohort of 2266 Aboriginal and non-Aboriginal children enrolled from primary schools throughout New South Wales from February 2002 to June 2004 and followed for 4 years. MAIN OUTCOME MEASURES: Urinalysis, height, weight, blood pressure, birthweight and sociodemographic status at baseline and 2- and 4-year follow-up; CKD risk factors: haematuria, albuminuria, obesity, and systolic and diastolic hypertension. RESULTS: 2266 children (55% Aboriginal; 51% male; mean age, 8.9 years [SD, 2.0 years]) were enrolled at baseline. 1432 children (63%) were retested at 2-year follow-up, and 1506 children (67%) at 4-year follow-up. Prevalence of baseline CKD risk factors was frequent (2%-7%), but most abnormalities were transient. Besides persistent obesity (5.0%), persistence of CKD risk factors at final follow-up was low: haematuria (1.9%), albuminuria (2.4%), systolic hypertension (1.5%) and diastolic hypertension (0.2%). There was no difference in prevalence of persistent CKD risk factors between Aboriginal and non-Aboriginal children. CONCLUSIONS: Over 4 years of follow-up, Indigenous Australian children had no increased risk for early evidence of CKD. More than 70% of baseline risk factors were transient, and persistent risk factors were uncommon. Our findings suggest the increased risk for end-stage kidney disease seen in Indigenous adults is not yet manifest in these schoolchildren, and may be potentially preventable.
OBJECTIVE: To describe the natural history and risk of early chronic kidney disease (CKD) in Indigenous Australian populations. DESIGN, SETTING AND PARTICIPANTS: A prospective cohort of 2266 Aboriginal and non-Aboriginal children enrolled from primary schools throughout New South Wales from February 2002 to June 2004 and followed for 4 years. MAIN OUTCOME MEASURES: Urinalysis, height, weight, blood pressure, birthweight and sociodemographic status at baseline and 2- and 4-year follow-up; CKD risk factors: haematuria, albuminuria, obesity, and systolic and diastolic hypertension. RESULTS: 2266 children (55% Aboriginal; 51% male; mean age, 8.9 years [SD, 2.0 years]) were enrolled at baseline. 1432 children (63%) were retested at 2-year follow-up, and 1506 children (67%) at 4-year follow-up. Prevalence of baseline CKD risk factors was frequent (2%-7%), but most abnormalities were transient. Besides persistent obesity (5.0%), persistence of CKD risk factors at final follow-up was low: haematuria (1.9%), albuminuria (2.4%), systolic hypertension (1.5%) and diastolic hypertension (0.2%). There was no difference in prevalence of persistent CKD risk factors between Aboriginal and non-Aboriginal children. CONCLUSIONS: Over 4 years of follow-up, Indigenous Australian children had no increased risk for early evidence of CKD. More than 70% of baseline risk factors were transient, and persistent risk factors were uncommon. Our findings suggest the increased risk for end-stage kidney disease seen in Indigenous adults is not yet manifest in these schoolchildren, and may be potentially preventable.
Authors: S Kim; P Macaskill; L A Baur; E M Hodson; J Daylight; R Williams; R Kearns; N Vukasin; D M Lyle; J C Craig Journal: Int J Obes (Lond) Date: 2016-04-28 Impact factor: 5.095
Authors: Siah Kim; Petra Macaskill; Elisabeth M Hodson; Jennifer Daylight; Rita Williams; Rachael Kearns; Nicola Vukasin; David M Lyle; Jonathan C Craig Journal: Pediatr Nephrol Date: 2016-06-23 Impact factor: 3.714
Authors: Lisa M Jamieson; Lisa G Smithers; Joanne Hedges; Jacqueline Aldis; Helen Mills; Kostas Kapellas; Herenia P Lawrence; John R Broughton; Xiangqun Ju Journal: JAMA Netw Open Date: 2019-03-01
Authors: Lisa M Jamieson; Joanne Hedges; X Ju; Kostas Kapellas; Cathy Leane; Dandara G Haag; Pedro Ribeiro Santiago; Davi Manzini Macedo; Rachel M Roberts; Lisa G Smithers Journal: BMJ Open Date: 2021-02-22 Impact factor: 2.692