Literature DB >> 19294716

Charge-conversional polyionic complex micelles-efficient nanocarriers for protein delivery into cytoplasm.

Yan Lee1, Takehiko Ishii, Horacio Cabral, Hyun Jin Kim, Ji-Hun Seo, Nobuhiro Nishiyama, Hiroki Oshima, Kensuke Osada, Kazunori Kataoka.   

Abstract

Special delivery! Polyionic complex (PIC) micelles that contain the charge-conversional moieties citaconic amide or cis-aconitic amide were developed for cytoplasmic protein delivery. The increase of the charge density on the protein cargo helped the stability of the PIC micelles without cross-linking, and the charge-conversion in endosomes induced the dissociation of the PIC micelles to result in efficient endosomal release (see picture).

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Year:  2009        PMID： 19294716     DOI： 10.1002/anie.200900064

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  29 in total

1.  Templated Self-Assembly of a Covalent Polymer Network for Intracellular Protein Delivery and Traceless Release.

Authors:  Kingshuk Dutta; Ding Hu; Bo Zhao; Alexander E Ribbe; Jiaming Zhuang; S Thayumanavan
Journal:  J Am Chem Soc       Date:  2017-04-13       Impact factor: 15.419

2.  The uptake of N-(2-hydroxypropyl)-methacrylamide based homo, random and block copolymers by human multi-drug resistant breast adenocarcinoma cells.

Authors:  Matthias Barz; Robert Luxenhofer; Rudolf Zentel; Alexander V Kabanov
Journal:  Biomaterials       Date:  2009-07-23       Impact factor: 12.479

3.  Structure-activity relationships of cationic shell-crosslinked knedel-like nanoparticles: shell composition and transfection efficiency/cytotoxicity.

Authors:  Ke Zhang; Huafeng Fang; Zhenghui Wang; Zhou Li; John-Stephen A Taylor; Karen L Wooley
Journal:  Biomaterials       Date:  2009-10-29       Impact factor: 12.479

4.  Intracellular Delivery of Nanobodies for Imaging of Target Proteins in Live Cells.

Authors:  Ruth Röder; Jonas Helma; Tobias Preiß; Joachim O Rädler; Heinrich Leonhardt; Ernst Wagner
Journal:  Pharm Res       Date:  2016-10-31       Impact factor: 4.200

5.  Advances in Anticancer Protein Delivery Using Micro-/ Nanoparticles.

Authors:  Wujin Sun; Yue Lu; Zhen Gu
Journal:  Part Part Syst Charact       Date:  2014-10-16       Impact factor: 3.310

6.  Integrating Combinatorial Lipid Nanoparticle and Chemically Modified Protein for Intracellular Delivery and Genome Editing.

Authors:  Jin Chang; Xianghan Chen; Zachary Glass; Feng Gao; Lanqun Mao; Ming Wang; Qiaobing Xu
Journal:  Acc Chem Res       Date:  2018-12-26       Impact factor: 22.384

Review 7.  Multifunctional nanoassemblies of block copolymers for future cancer therapy.

Authors:  Horacio Cabral; Kazunori Kataoka
Journal:  Sci Technol Adv Mater       Date:  2010-04-16       Impact factor: 8.090

8.  Advances in Polymer and Polymeric Nanostructures for Protein Conjugation.

Authors:  Daniella C González-Toro; S Thayumanavan
Journal:  Eur Polym J       Date:  2013-10-01       Impact factor: 4.598

Review 9.  Cooperativity Principles in Self-Assembled Nanomedicine.

Authors:  Yang Li; Yiguang Wang; Gang Huang; Jinming Gao
Journal:  Chem Rev       Date:  2018-04-25       Impact factor: 60.622

10.  Delivery of intact transcription factor by using self-assembled supramolecular nanoparticles.

Authors:  Yang Liu; Hao Wang; Ken-ichiro Kamei; Ming Yan; Kuan-Ju Chen; Qinghua Yuan; Linqi Shi; Yunfeng Lu; Hsian-Rong Tseng
Journal:  Angew Chem Int Ed Engl       Date:  2011-03-02       Impact factor: 15.336
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