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Literature DB >> 1929322

Inhibition of Cryptosporidium parvum in neonatal Hsd:(ICR)BR Swiss miceby polyether ionophores and aromatic amidines.

B L Blagburn¹, C A Sundermann, D S Lindsay, J E Hall, R R Tidwell.

Abstract

Cryptosporidicidal effects of two polyether ionophores (maduramicin and alborixin), a fluorinated 4-quinolone (enrofloxacin), and three analogs of pentamidine were evaluated in a suckling mouse bioassay. Treatment with all compounds except enrofloxacin and one of the pentamidine analogs [1,3-di(4-imidazolinophenoxy)propane] resulted in significant (P less than 0.05) reductions in oocyst excretion.

Entities: Chemical Disease Species

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Year: 1991 PMID： 1929322 PMCID： PMC245207 DOI： 10.1128/AAC.35.7.1520

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

11 in total

1. In vitro cultivation of Cryptosporidium parvum and screening for anticryptosporidial drugs.

Authors: V McDonald; R Stables; D C Warhurst; M R Barer; D A Blewett; H D Chapman; G M Connolly; P L Chiodini; K P McAdam
Journal: Antimicrob Agents Chemother Date: 1990-08 Impact factor: 5.191

2. Analogues of 1,5-bis(4-amidinophenoxy)pentane (pentamidine) in the treatment of experimental Pneumocystis carinii pneumonia.

Authors: R R Tidwell; S K Jones; J D Geratz; K A Ohemeng; M Cory; J E Hall
Journal: J Med Chem Date: 1990-04 Impact factor: 7.446

3. Novel pentamidine analogs in the treatment of experimental Pneumocystis carinii pneumonia.

Authors: S K Jones; J E Hall; M A Allen; S D Morrison; K A Ohemeng; V V Reddy; J D Geratz; R R Tidwell
Journal: Antimicrob Agents Chemother Date: 1990-06 Impact factor: 5.191

4. Attempted chemoprophylaxis of cryptosporidiosis in calves.

Authors: H W Moon; G N Woode; F A Ahrens
Journal: Vet Rec Date: 1982-02-20 Impact factor: 2.695

5. Experimental cryptosporidiosis in laboratory mice.

Authors: D Sherwood; K W Angus; D R Snodgrass; S Tzipori
Journal: Infect Immun Date: 1982-11 Impact factor: 3.441

6. Structure-activity relationships of analogs of pentamidine against Plasmodium falciparum and Leishmania mexicana amazonensis.

Authors: C A Bell; J E Hall; D E Kyle; M Grogl; K A Ohemeng; M A Allen; R R Tidwell
Journal: Antimicrob Agents Chemother Date: 1990-07 Impact factor: 5.191

7. The species of Cryptosporidium (Apicomplexa: Cryptosporidiidae) infecting mammals.

Authors: S J Upton; W L Current
Journal: J Parasitol Date: 1985-10 Impact factor: 1.276

8. Cryptosporidiosis in homosexual men.

Authors: R Soave; R L Danner; C L Honig; P Ma; C C Hart; T Nash; R B Roberts
Journal: Ann Intern Med Date: 1984-04 Impact factor: 25.391

9. The therapeutic effect of 16 antimicrobial agents on Cryptosporidium infection in mice.

Authors: S R Tzipori; I Campbell; K W Angus
Journal: Aust J Exp Biol Med Sci Date: 1982-04

10. Characterization of cyclophosphamide-rat model of cryptosporidiosis.

Authors: J E Rehg; M L Hancock; D B Woodmansee
Journal: Infect Immun Date: 1987-11 Impact factor: 3.441

11 in total

1. Cyclosporin analogs inhibit in vitro growth of Cryptosporidium parvum.

Authors: M E Perkins; T W Wu; S M Le Blancq
Journal: Antimicrob Agents Chemother Date: 1998-04 Impact factor: 5.191

2. Activity of cationically substituted bis-benzimidazoles against experimental Pneumocystis carinii pneumonia.

Authors: R R Tidwell; S K Jones; N A Naiman; L C Berger; W B Brake; C C Dykstra; J E Hall
Journal: Antimicrob Agents Chemother Date: 1993-08 Impact factor: 5.191

3. Anti-Pneumocystis activities of aromatic diamidoxime prodrugs.

Authors: J E Hall; J E Kerrigan; K Ramachandran; B C Bender; J P Stanko; S K Jones; D A Patrick; R R Tidwell
Journal: Antimicrob Agents Chemother Date: 1998-03 Impact factor: 5.191

4. Comparative efficacy evaluation of dicationic carbazole compounds, nitazoxanide, and paromomycin against Cryptosporidium parvum infections in a neonatal mouse model.

Authors: B L Blagburn; K L Drain; T M Land; R G Kinard; P H Moore; D S Lindsay; D A Patrick; D W Boykin; R R Tidwell
Journal: Antimicrob Agents Chemother Date: 1998-11 Impact factor: 5.191

5. Polyether ionophores: broad-spectrum and promising biologically active molecules for the control of drug-resistant bacteria and parasites.

Authors: Dion A Kevin Ii; Damaris Af Meujo; Mark T Hamann
Journal: Expert Opin Drug Discov Date: 2009-02 Impact factor: 6.098

6. Bovine antibody against Cryptosporidium parvum elicits a circumsporozoite precipitate-like reaction and has immunotherapeutic effect against persistent cryptosporidiosis in SCID mice.

Authors: M W Riggs; V A Cama; H L Leary; C R Sterling
Journal: Infect Immun Date: 1994-05 Impact factor: 3.441

7. Selective inhibition of topoisomerases from Pneumocystis carinii compared with that of topoisomerases from mammalian cells.

Authors: C C Dykstra; D R McClernon; L P Elwell; R R Tidwell
Journal: Antimicrob Agents Chemother Date: 1994-09 Impact factor: 5.191

Review 8. Novel amidines and analogues as promising agents against intracellular parasites: a systematic review.

Authors: M N C Soeiro; K Werbovetz; D W Boykin; W D Wilson; M Z Wang; A Hemphill
Journal: Parasitology Date: 2013-04-08 Impact factor: 3.234

9. Structure-in vitro activity relationships of pentamidine analogues and dication-substituted bis-benzimidazoles as new antifungal agents.

Authors: M Del Poeta; W A Schell; C C Dykstra; S Jones; R R Tidwell; A Czarny; M Bajic; A Kumar; D Boykin; J R Perfect
Journal: Antimicrob Agents Chemother Date: 1998-10 Impact factor: 5.191

10. Evaluation of maduramicin and alborixin in a SCID mouse model of chronic cryptosporidiosis.

Authors: J R Mead; X You; J E Pharr; Y Belenkaya; M J Arrowood; M T Fallon; R F Schinazi
Journal: Antimicrob Agents Chemother Date: 1995-04 Impact factor: 5.191