Literature DB >> 1929265

Effect of beta-lactamase inhibitors on the activities of various beta-lactam agents against anaerobic bacteria.

H M Wexler1, E Molitoris, S M Finegold.   

Abstract

The in vitro activities of several new beta-lactam-beta-lactamase inhibitor combinations (piperacillin plus tazobactam, ceftizoxime and cefonicid with sulbactam and clavulanic acid, and ampicillin plus 8 micrograms of sulbactam per ml) were tested with anaerobic bacteria and compared with known beta-lactam-beta-lactamase inhibitor combinations and other potent antianaerobe agents. All the combinations tested (except for the cefonicid-inhibitor combinations) were active against almost all strains of the Bacteroides fragilis group. This report indicates that beta-lactamase inhibitors may improve the activity of beta-lactam agents with marginal activity against the B. fragilis group.

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Year:  1991        PMID： 1929265      PMCID： PMC284314          DOI： 10.1128/AAC.35.6.1219

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

1.  In vitro activity of cefoperazone plus sulbactam compared with that of other antimicrobial agents against anaerobic bacteria.

Authors:  H M Wexler; S M Finegold
Journal:  Antimicrob Agents Chemother       Date:  1988-03       Impact factor: 5.191

2.  Emergence of beta-lactamase producing anaerobic bacteria in the tonsils during penicillin treatment.

Authors:  K Tunér; C E Nord
Journal:  Eur J Clin Microbiol       Date:  1986-08       Impact factor: 3.267

Review 3.  Antimicrobial resistance in Bacteroides.

Authors:  H M Wexler; S M Finegold
Journal:  J Antimicrob Chemother       Date:  1987-02       Impact factor: 5.790

4.  The beta-lactamases of Bacteroides species.

Authors:  R Timewell; E Taylor; I Phillips
Journal:  J Antimicrob Chemother       Date:  1981-02       Impact factor: 5.790

5.  Comparative activity of beta-lactamase inhibitors YTR 830, clavulanate, and sulbactam combined with beta-lactams against beta-lactamase-producing anaerobes.

Authors:  P C Appelbaum; M R Jacobs; S K Spangler; S Yamabe
Journal:  Antimicrob Agents Chemother       Date:  1986-11       Impact factor: 5.191

6.  Bacteroides gracilis, an important anaerobic bacterial pathogen.

Authors:  C C Johnson; J F Reinhardt; M A Edelstein; M E Mulligan; W L George; S M Finegold
Journal:  J Clin Microbiol       Date:  1985-11       Impact factor: 5.948

7.  The activity of ticarcillin in combination with clavulanic acid against Bacteroides species: an in-vitro comparison with other antibiotics.

Authors:  B de Barbeyrac; C Quentin; C Bébéar
Journal:  J Antimicrob Chemother       Date:  1986-05       Impact factor: 5.790

8.  Antimicrobial susceptibilities of 1,292 isolates of the Bacteroides fragilis group in the United States: comparison of 1981 with 1982.

Authors:  G J Cuchural; F P Tally; N V Jacobus; S L Gorbach; K Aldridge; T Cleary; S M Finegold; G Hill; P Iannini; J P O'Keefe
Journal:  Antimicrob Agents Chemother       Date:  1984-08       Impact factor: 5.191

9.  Effect of clavulanic acid on the activities of ten beta-lactam agents against members of the Bacteroides fragilis group.

Authors:  F Lamothe; F Auger; J M Lacroix
Journal:  Antimicrob Agents Chemother       Date:  1984-05       Impact factor: 5.191

10.  Activity of newer beta-lactam agents against clinical isolates of Bacteroides fragilis and other Bacteroides species.

Authors:  J P O'Keefe; F R Venezio; C A DiVincenzo; K L Shatzer
Journal:  Antimicrob Agents Chemother       Date:  1987-12       Impact factor: 5.191
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  6 in total

Review 1.  Current antimicrobial therapy of anaerobic infections.

Authors:  C V Sanders; K E Aldridge
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1992-11       Impact factor: 3.267

2.  In vitro activity of ceftriaxone combined with tazobactam against anaerobic bacteria.

Authors:  J Wüst; U Hardegger
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1994-02       Impact factor: 3.267

3.  Survey of Bacteroides fragilis group susceptibility patterns in Canada.

Authors:  A M Bourgault; F Lamothe; D J Hoban; M T Dalton; P C Kibsey; G Harding; J A Smith; D E Low; H Gilbert
Journal:  Antimicrob Agents Chemother       Date:  1992-02       Impact factor: 5.191

4.  Susceptibilities of 540 anaerobic gram-negative bacilli to amoxicillin, amoxicillin-BRL 42715, amoxicillin-clavulanate, temafloxacin, and clindamycin.

Authors:  P C Appelbaum; S K Spangler; R Shiman; M R Jacobs
Journal:  Antimicrob Agents Chemother       Date:  1992-05       Impact factor: 5.191

5.  Longitudinal study of susceptibilities of species of the Bacteroides fragilis group to five antimicrobial agents in three medical centers.

Authors:  P Turgeon; V Turgeon; M Gourdeau; J Dubois; F Lamothe
Journal:  Antimicrob Agents Chemother       Date:  1994-10       Impact factor: 5.191

Review 6.  Piperacillin/tazobactam. A review of its antibacterial activity, pharmacokinetic properties and therapeutic potential.

Authors:  H M Bryson; R N Brogden
Journal:  Drugs       Date:  1994-03       Impact factor: 9.546
  6 in total

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