| Literature DB >> 19290662 |
Min Lu1, Di Zhu, Yunpeng Lu, Xiaofei Zeng, Bin Tan, Zhenjiang Xu, Guofu Zhong.
Abstract
A novel, facile, and highly enantioselective Brønsted acid-catalyzed alpha-hydroxylation of beta-dicarbonyl compounds with up to 99:1 er using nitroso compounds as the oxygen source has been developed. The results disclosed herein considerably extend the substrate scope for the alpha-aminoxylation, allowing expeditious, straightforward, and efficient access to valuable alpha-hydroxy-beta-dicarbonyl compounds with the highest levels of enantiocontrol.Entities:
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Year: 2009 PMID： 19290662 DOI： 10.1021/ja8088907
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419