Literature DB >> 19289123

Interleukin-1beta is a positive regulator of TIARP/STAMP2 gene and protein expression in adipocytes in vitro.

Susan Kralisch1, Grit Sommer, Sebastian Weise, Jana Lipfert, Ulrike Lossner, Manja Kamprad, Kathleen Schröck, Matthias Bluher, Michael Stumvoll, Mathias Fasshauer.   

Abstract

The impact of interleukin (IL)-1beta on tumor necrosis factor alpha-induced adipose-related protein (TIARP)/six-transmembrane protein of prostate 2 (STAMP2) was determined in adipocytes. TIARP/STAMP2 mRNA synthesis was significantly stimulated by IL-1beta in a dose- and time-dependent fashion in 3T3-L1 adipocytes. Signaling studies suggested that janus kinase 2, nuclear factor kappaB, and p44/42 mitogen-activated protein kinase are involved in IL-1beta-induced TIARP/STAMP2 mRNA expression. Furthermore, IL-1beta, TNFalpha, and IL-6 showed synergistic stimulatory effects on TIARP/STAMP2 gene expression. Moreover, both TIARP/STAMP2 mRNA synthesis and protein expression were induced by IL-1beta in fully differentiated human mesenchymal stem cell-derived adipocytes (hMSC-Ad). Taken together, TIARP/STAMP2 is highly upregulated in 3T3-L1 cells and hMSC-Ad by IL-1beta and might, therefore, modulate proinflammatory and insulin resistance-inducing effects of IL-1beta.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19289123     DOI： 10.1016/j.febslet.2009.03.015

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  15 in total

1.  STEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation.

Authors:  Hannah M Gordon; Neil Majithia; Patrick E MacDonald; Jocelyn E Manning Fox; Poonam R Sharma; Frances L Byrne; Kyle L Hoehn; Carmella Evans-Molina; Linda Langman; Kenneth L Brayman; Craig S Nunemaker
Journal:  Endocrine       Date:  2017-04-12       Impact factor: 3.633

2.  Clinical and functional significance of STEAP4-splice variant in CD14+ monocytes in patients with rheumatoid arthritis.

Authors:  H Ebe; I Matsumoto; H Kawaguchi; I Kurata; Y Tanaka; A Inoue; Y Kondo; H Tsuboi; T Sumida
Journal:  Clin Exp Immunol       Date:  2017-11-16       Impact factor: 4.330

3.  Genetic Variants in Six-Transmembrane Epithelial Antigen of Prostate 4 Increase Risk of Developing Metabolic Syndrome in a Han Chinese Population.

Authors:  Yue Qi; Yaqin Yu; Yanhua Wu; Shibin Wang; Qiong Yu; Jieping Shi; Ziqi Xu; Qingqing Zhang; Yingli Fu; Yao Fu; Changgui Kou
Journal:  Genet Test Mol Biomarkers       Date:  2015-10-28

4.  Adipocyte fatty acid-binding protein is released from adipocytes by a non-conventional mechanism.

Authors:  S Kralisch; T Ebert; U Lossner; B Jessnitzer; M Stumvoll; M Fasshauer
Journal:  Int J Obes (Lond)       Date:  2013-12-13       Impact factor: 5.095

Review 5.  STEAP4: its emerging role in metabolism and homeostasis of cellular iron and copper.

Authors:  Rachel T Scarl; C Martin Lawrence; Hannah M Gordon; Craig S Nunemaker
Journal:  J Endocrinol       Date:  2017-06-02       Impact factor: 4.286

6.  An Islet-Targeted Genome-Wide Association Scan Identifies Novel Genes Implicated in Cytokine-Mediated Islet Stress in Type 2 Diabetes.

Authors:  Poonam R Sharma; Aaron J Mackey; Eden A Dejene; James W Ramadan; Carl D Langefeld; Nicholette D Palmer; Kent D Taylor; Lynne E Wagenknecht; Richard M Watanabe; Stephen S Rich; Craig S Nunemaker
Journal:  Endocrinology       Date:  2015-05-27       Impact factor: 4.736

7.  Murine double minute 2 aggravates adipose tissue dysfunction through ubiquitin-mediated six-transmembrane epithelial antigen of prostate 4 degradation.

Authors:  Wei Zhao; Qiang Xu; Jiahui Yang; Xianghong Xie; Chunmei Li; Weihong Zhang; Enhui Chen; Yanfang Guo; Mingyue Gao; Jie Shi; Huabing Zhang; Hong Yao; Meixia Li; Li Yan; Fude Fang; Wenming Wu; Xiaojun Liu
Journal:  iScience       Date:  2022-06-07

8.  The crystal structure of six-transmembrane epithelial antigen of the prostate 4 (Steap4), a ferri/cuprireductase, suggests a novel interdomain flavin-binding site.

Authors:  George H Gauss; Mark D Kleven; Anoop K Sendamarai; Mark D Fleming; C Martin Lawrence
Journal:  J Biol Chem       Date:  2013-06-03       Impact factor: 5.157

Review 9.  STEAP4 and insulin resistance.

Authors:  Xiaoling Chen; Zhiqing Huang; Bo Zhou; Huan Wang; Gang Jia; Guangmang Liu; Hua Zhao
Journal:  Endocrine       Date:  2014-03-14       Impact factor: 3.633

10.  Hepatic STAMP2 decreases hepatitis B virus X protein-associated metabolic deregulation.

Authors:  Hye Young Kim; Hyun Kook Cho; Seong Keun Yoo; Jae Hun Cheong
Journal:  Exp Mol Med       Date:  2012-10-31       Impact factor: 8.718
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.