Literature DB >> 19286427

Simple and rapid liquid chromatography method for determination of moxifloxacin in plasma.

A K Hemanth Kumar1, Geetha Ramachandran.   

Abstract

A high performance liquid chromatographic method for determination of moxifloxacin in human plasma was developed. The method involved deproteinisation of the sample with perchloric acid and analysis of the supernatant using a reversed-phase C(18) column (150 mm) and fluorescence detection at an excitation wavelength of 290 nm and an emission wavelength of 460 nm. The assay was specific for moxifloxacin and linear from 0.125 to 10.0 microg/ml. The relative standard deviation of intra- and inter-day assays was lower than 10%. The average recovery of moxifloxacin from plasma was 101%. Due to its simplicity, the assay can be used for pharmacokinetic studies of moxifloxacin.

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Year:  2009        PMID： 19286427     DOI： 10.1016/j.jchromb.2009.02.042

Source DB:  PubMed          Journal:  J Chromatogr B Analyt Technol Biomed Life Sci        ISSN： 1570-0232            Impact factor:   3.205


  8 in total

1.  Biopharmaceutical characterization of nebulized antimicrobial agents in rats: 1. Ciprofloxacin, moxifloxacin, and grepafloxacin.

Authors:  Aline Vidal Lacerda Gontijo; Julien Brillault; Nicolas Grégoire; Isabelle Lamarche; Patrice Gobin; William Couet; Sandrine Marchand
Journal:  Antimicrob Agents Chemother       Date:  2014-05-05       Impact factor: 5.191

2.  Development and validation of spectrophotometric, atomic absorption and kinetic methods for determination of moxifloxacin hydrochloride.

Authors:  Lobna M Abdellaziz; Mervat M Hosny
Journal:  Anal Chem Insights       Date:  2011-11-07

3.  Potentiometric determination of moxifloxacin in some pharmaceutical formulation using PVC membrane sensors.

Authors:  Mohammed M Hefnawy; Atef M Homoda; Mohammed A Abounassif; Amer M Alanazi; Abdulrahaman Al-Majed; Gamal A Mostafa
Journal:  Chem Cent J       Date:  2014-09-17       Impact factor: 4.215

4.  Effect of rifampicin & isoniazid on the steady state pharmacokinetics of moxifloxacin.

Authors:  Geetha Ramachandran; A K Hemanth Kumar; R Srinivasan; A Geetharani; P Sugirda; B Nandhakumar; R Nandini; C B Tharani
Journal:  Indian J Med Res       Date:  2012-12       Impact factor: 2.375

5.  Improved HPLC method for the determination of moxifloxacin in application to a pharmacokinetics study in patients with infectious diseases.

Authors:  Nan Wang; Liqin Zhu; Xuequn Zhao; Wenjie Yang; He Sun
Journal:  ISRN Pharmacol       Date:  2013-05-26

6.  High-performance liquid chromatography assay for moxifloxacin in brain tissue and plasma: validation in a pharmacokinetic study in a murine model of cerebral listeriosis.

Authors:  Renaud Respaud; Solene Grayo; Eric Singlas; Sophie Dubouch; Alban Le Monnier; Marie-Catherine Lott
Journal:  J Anal Methods Chem       Date:  2012-03-14       Impact factor: 2.193

7.  validated microbiological and HPLC methods for the determination of moxifloxacin in pharmaceutical preparations and human plasma.

Authors:  Ahmed A Abdelaziz; Tarek E Elbanna; Noha M Gamaleldeen
Journal:  Braz J Microbiol       Date:  2012-06-01       Impact factor: 2.476

8.  Suboptimal Antituberculosis Drug Concentrations and Outcomes in Small and HIV-Coinfected Children in India: Recommendations for Dose Modifications.

Authors:  Benjamin Guiastrennec; Geetha Ramachandran; Mats O Karlsson; A K Hemanth Kumar; Perumal Kannabiran Bhavani; N Poorana Gangadevi; Soumya Swaminathan; Amita Gupta; Kelly E Dooley; Radojka M Savic
Journal:  Clin Pharmacol Ther       Date:  2018-02-02       Impact factor: 6.875
  8 in total

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