PURPOSE: A possible association between thyroid diseases (TD) and breast cancer (BC) has been debated. We examined prevalence and development of TD in women after multimodal treatment for Stage II/III BC compared with women from a general population. Secondarily, we explored the impact of two different radiotherapy (RT) techniques (standardized field arrangements vs. computed tomography [CT]-based dose planning) on TD in BC patients examined 35-120 months after primary BC treatment. METHODS AND MATERIALS: A total of 403 BC patients completed a questionnaire about TD and had blood samples taken for analyses of thyroid function. All had undergone postoperative RT with or without (2%) adjuvant systemic treatment. The results in the BC patients were compared with a cancer-free, age-matched control group from a general population (CGr). RESULTS: There was higher prevalence of self-reported hypothyroidism in the BC patients as compared with the CGr (18% vs. 6%, p < 0.001). The raised prevalence was predominantly due to a substantial increase in the development of hypothyroidism after BC diagnosis, whereas the prevalence of hypothyroidism before BC diagnosis was similar to that observed in the CGr. Patients treated with CT-based RT showed a trend for increased post-BC development of hypothyroidism as compared with those treated with standardized field arrangements (p = 0.08). CONCLUSIONS: Hypothyroidism is significantly increased in women after multimodal treatment for Stage II/III BC. Radiation to the thyroid gland may be a contributing factor. BC patients should be routinely screened for hypothyroidism.
PURPOSE: A possible association between thyroid diseases (TD) and breast cancer (BC) has been debated. We examined prevalence and development of TD in women after multimodal treatment for Stage II/III BC compared with women from a general population. Secondarily, we explored the impact of two different radiotherapy (RT) techniques (standardized field arrangements vs. computed tomography [CT]-based dose planning) on TD in BC patients examined 35-120 months after primary BC treatment. METHODS AND MATERIALS: A total of 403 BC patients completed a questionnaire about TD and had blood samples taken for analyses of thyroid function. All had undergone postoperative RT with or without (2%) adjuvant systemic treatment. The results in the BC patients were compared with a cancer-free, age-matched control group from a general population (CGr). RESULTS: There was higher prevalence of self-reported hypothyroidism in the BC patients as compared with the CGr (18% vs. 6%, p < 0.001). The raised prevalence was predominantly due to a substantial increase in the development of hypothyroidism after BC diagnosis, whereas the prevalence of hypothyroidism before BC diagnosis was similar to that observed in the CGr. Patients treated with CT-based RT showed a trend for increased post-BC development of hypothyroidism as compared with those treated with standardized field arrangements (p = 0.08). CONCLUSIONS:Hypothyroidism is significantly increased in women after multimodal treatment for Stage II/III BC. Radiation to the thyroid gland may be a contributing factor. BC patients should be routinely screened for hypothyroidism.
Authors: Alv A Dahl; Saevar Berg Gudbergsson; Anne Dørum; Sophie D Fosså; Astrid H Liavaag; Øystein Sørebø Journal: Qual Life Res Date: 2011-11-02 Impact factor: 4.147
Authors: Ashlesha Patel; Alicia Roston; Almae Uy; Erika Radeke; Arden Roston; Louis Keith; H A Zaren Journal: Support Care Cancer Date: 2014-08-15 Impact factor: 3.603
Authors: L Darvish; M Ghorbani; S Hosseini Teshnizi; N Roozbeh; F Seif; M Reza Bayatiani; C Knaup; A Amraee Journal: Clin Transl Oncol Date: 2018-05-14 Impact factor: 3.405
Authors: Safora Johansen; Kristin H Tjessem; Kristian Fosså; Gerhard Bosse; Turi Danielsen; Eirik Malinen; Sophie D Fosså Journal: Breast Cancer (Auckl) Date: 2013-03-20