Literature DB >> 19285791

Naïve human umbilical cord matrix derived stem cells significantly attenuate growth of human breast cancer cells in vitro and in vivo.

Rie Ayuzawa1, Chiyo Doi, Raja Shekar Rachakatla, Marla M Pyle, Dharmendra Kumar Maurya, Deryl Troyer, Masaaki Tamura.   

Abstract

The effect of un-engineered (naïve) human umbilical cord matrix stem cells (hUCMSC) on the metastatic growth of MDA 231 xenografts in SCID mouse lung was examined. Three weekly IV injections of 5x10(5) hUCMSC significantly attenuated MDA 231 tumor growth as compared to the saline-injected control. IV injected hUCMSC were detected only within tumors or in close proximity to the tumors. This in vivo result was corroborated by multiple in vitro studies such as colony assay in soft agar and [(3)H]-thymidine uptake. These results suggest that naïve hUCMSC may be a useful tool for cancer cytotherapy.

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Year:  2009        PMID： 19285791      PMCID： PMC2914472          DOI： 10.1016/j.canlet.2009.02.011

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  26 in total

Review 1.  Embryonic stem cells: An exciting field for basic research and tissue engineering, but also an ethical dilemma?

Authors:  H W Denker
Journal:  Cells Tissues Organs       Date:  1999       Impact factor: 2.481

Review 2.  Stem cells: hype or hope?

Authors:  Gesine Paul; Jia-Yi Li; Patrik Brundin
Journal:  Drug Discov Today       Date:  2002-03-01       Impact factor: 7.851

Review 3.  The therapeutic potential of stem cells from adults.

Authors:  Ingrid Kuehnle; Margaret A Goodell
Journal:  BMJ       Date:  2002-08-17

4.  Induction of ductal and stromal hyperplasia by basic fibroblast growth factor produced by human pancreatic carcinoma.

Authors:  H Kuniyasu; J L Abbruzzese; K R Cleary; I J Fidler
Journal:  Int J Oncol       Date:  2001-10       Impact factor: 5.650

Review 5.  Human embryonic stem cells: research, ethics and policy.

Authors:  Guido de Wert; Christine Mummery
Journal:  Hum Reprod       Date:  2003-04       Impact factor: 6.918

6.  Highly proliferative intratumoral fibroblasts and a high proliferative microvessel index are significant predictors of tumor metastasis in T3 ulcerative-type colorectal cancer.

Authors:  T Hasebe; S Sasaki; M Sugitoh; M Ono; N Saitoh; A Ochiai
Journal:  Hum Pathol       Date:  2001-04       Impact factor: 3.466

7.  Immune properties of human umbilical cord Wharton's jelly-derived cells.

Authors:  Mark L Weiss; Cameron Anderson; Satish Medicetty; Kiran B Seshareddy; Rita J Weiss; Irene VanderWerff; Deryl Troyer; Kevin R McIntosh
Journal:  Stem Cells       Date:  2008-08-14       Impact factor: 6.277

8.  Bone marrow-derived mesenchymal stem cells as vehicles for interferon-beta delivery into tumors.

Authors:  Matus Studeny; Frank C Marini; Richard E Champlin; Claudia Zompetta; Isaiah J Fidler; Michael Andreeff
Journal:  Cancer Res       Date:  2002-07-01       Impact factor: 12.701

9.  Matrix cells from Wharton's jelly form neurons and glia.

Authors:  Kathy E Mitchell; Mark L Weiss; Brianna M Mitchell; Phillip Martin; Duane Davis; Lois Morales; Bryan Helwig; Mark Beerenstrauch; Khalil Abou-Easa; Tammi Hildreth; Deryl Troyer; Satish Medicetty
Journal:  Stem Cells       Date:  2003       Impact factor: 6.277

Review 10.  Human embryonic or adult stem cells: an overview on ethics and perspectives for tissue engineering.

Authors:  Philippe R Henon
Journal:  Adv Exp Med Biol       Date:  2003       Impact factor: 2.622
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  46 in total

1.  Over-expression of angiotensin II type 2 receptor gene induces cell death in lung adenocarcinoma cells.

Authors:  Lara Pickel; Takaya Matsuzuka; Chiyo Doi; Rie Ayuzawa; Dharmendra Kumar Maurya; Sheng-Xue Xie; Cory Berkland; Masaaki Tamura
Journal:  Cancer Biol Ther       Date:  2009-12-22       Impact factor: 4.742

2.  Angiotensin II type 2 receptor signaling significantly attenuates growth of murine pancreatic carcinoma grafts in syngeneic mice.

Authors:  Chiyo Doi; Noboru Egashira; Atsushi Kawabata; Dharmendra Kumar Maurya; Naomi Ohta; Deepthi Uppalapati; Rie Ayuzawa; Lara Pickel; Yuka Isayama; Deryl Troyer; Susumu Takekoshi; Masaaki Tamura
Journal:  BMC Cancer       Date:  2010-02-24       Impact factor: 4.430

3.  Mesenchymal stem cells in preclinical cancer cytotherapy: a systematic review.

Authors:  Ioannis Christodoulou; Maria Goulielmaki; Marina Devetzi; Mihalis Panagiotidis; Georgios Koliakos; Vassilis Zoumpourlis
Journal:  Stem Cell Res Ther       Date:  2018-12-07       Impact factor: 6.832

Review 4.  The therapeutic potential, challenges and future clinical directions of stem cells from the Wharton's jelly of the human umbilical cord.

Authors:  Ariff Bongso; Chui-Yee Fong
Journal:  Stem Cell Rev Rep       Date:  2013-04       Impact factor: 5.739

5.  Isolation and characterisation of mesenchymal stem cells derived from human placenta tissue.

Authors:  Shalini Vellasamy; Pratheep Sandrasaigaran; Sharmili Vidyadaran; Elizabeth George; Rajesh Ramasamy
Journal:  World J Stem Cells       Date:  2012-06-26       Impact factor: 5.326

6.  Human umbilical cord Wharton's jelly stem cells undergo enhanced chondrogenic differentiation when grown on nanofibrous scaffolds and in a sequential two-stage culture medium environment.

Authors:  Chui-Yee Fong; Arjunan Subramanian; Kalamegam Gauthaman; Jayarama Venugopal; Arijit Biswas; Seeram Ramakrishna; Ariff Bongso
Journal:  Stem Cell Rev Rep       Date:  2012-03       Impact factor: 5.739

7.  Human Wharton's jelly stem cells, its conditioned medium and cell-free lysate inhibit the growth of human lymphoma cells.

Authors:  Hao Daniel Lin; Chui Yee Fong; Arijit Biswas; Mahesh Choolani; Ariff Bongso
Journal:  Stem Cell Rev Rep       Date:  2014-08       Impact factor: 5.739

8.  Induction of Immunogenic Cell Death in Lymphoma Cells by Wharton's Jelly Mesenchymal Stem Cell Conditioned Medium.

Authors:  Daniel Hao Lin; Arijit Biswas; Mahesh Choolani; Chui-Yee Fong; Ariff Bongso
Journal:  Stem Cell Rev Rep       Date:  2017-12       Impact factor: 5.739

9.  Naïve rat umbilical cord matrix stem cells significantly attenuate mammary tumor growth through modulation of endogenous immune responses.

Authors:  Atsushi Kawabata; Naomi Ohta; Garret Seiler; Marla M Pyle; Susumu Ishiguro; Yong Qing Zhang; Kevin G Becker; Deryl Troyer; Masaaki Tamura
Journal:  Cytotherapy       Date:  2013-03-07       Impact factor: 5.414

10.  Therapy with un-engineered naïve rat umbilical cord matrix stem cells markedly inhibits growth of murine lung adenocarcinoma.

Authors:  Dharmendra K Maurya; Chiyo Doi; Atsushi Kawabata; Marla M Pyle; Clay King; Zhihong Wu; Deryl Troyer; Masaaki Tamura
Journal:  BMC Cancer       Date:  2010-10-28       Impact factor: 4.430
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