Literature DB >> 12903709

Human embryonic or adult stem cells: an overview on ethics and perspectives for tissue engineering.

Philippe R Henon1.   

Abstract

Over the past few years, research on animal and human stem cells has experienced tremendous advances which are almost daily loudly revealed to the public on the front-page of newspapers. The reason for such an enthusiasm over stem cells is that they could be used to cure patients suffering from spontaneous or injuries-related diseases that are due to particular types of cells functioning incorrectly, such as cardiomyopathy, diabetes mellitus, osteoporosis, cancers, Parkinson's disease, spinal cord injuries or genetic abnormalities. Currently, these diseases have slightly or non-efficient treatment options, and millions of people around the world are desperately waiting to be cured. Even if not any person with one of these diseases could potentially benefit from stem cell therapy, the new concept of "regenerative medicine" is unprecedented since it involves the regeneration of normal cells, tissues and organs which could allow to treat a patient whereby both, the immediate problem would be corrected and the normal physiological processes restored, without any need for subsequent drugs. However, conflicting ethical controversies surround this new medicine approach, inside and outside the medical community, especially when human embryonic stem cells (h-ESCs) are concerned. This ethical debate on clinical use of h-ESCs has recently encouraged the research on "adult" stem cells (ASCs) regarded as a less conflicting alternative for the future of regenerative medicine.

Entities:  

Keywords:  Biomedical and Behavioral Research; Genetics and Reproduction

Mesh:

Year:  2003        PMID: 12903709     DOI: 10.1007/978-1-4615-0063-6_3

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN: 0065-2598            Impact factor:   2.622


  5 in total

Review 1.  Transplantation of umbilical cord blood stem cells for treating spinal cord injury.

Authors:  Dong-Hyuk Park; Jeong-Hyun Lee; Cesario V Borlongan; Paul R Sanberg; Yong-Gu Chung; Tai-Hyoung Cho
Journal:  Stem Cell Rev Rep       Date:  2011-03       Impact factor: 5.739

Review 2.  Can we build synthetic, multicellular systems by controlling developmental signaling in space and time?

Authors:  Rustem F Ismagilov; Michel M Maharbiz
Journal:  Curr Opin Chem Biol       Date:  2007-11-19       Impact factor: 8.822

3.  Naïve human umbilical cord matrix derived stem cells significantly attenuate growth of human breast cancer cells in vitro and in vivo.

Authors:  Rie Ayuzawa; Chiyo Doi; Raja Shekar Rachakatla; Marla M Pyle; Dharmendra Kumar Maurya; Deryl Troyer; Masaaki Tamura
Journal:  Cancer Lett       Date:  2009-03-13       Impact factor: 8.679

4.  Improvement of Contused Spinal Cord in Rats by Cholinergic-like Neuron Therapy.

Authors:  Majid Naghdi; Taki Tiraihi; Seyed Alireza Mesbah-Namin; Jalil Arabkharadmand; Hadi Kazemi; Taher Taheri
Journal:  Iran Red Crescent Med J       Date:  2013-02-05       Impact factor: 0.611

5.  A modified efficient method for dental pulp stem cell isolation.

Authors:  Maryam Raoof; Mohammad Mehdi Yaghoobi; Ali Derakhshani; Ali Mohammadi Kamal-Abadi; Behnam Ebrahimi; Mehdi Abbasnejad; Noushin Shokouhinejad
Journal:  Dent Res J (Isfahan)       Date:  2014-03
  5 in total

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