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Literature DB >> 19283418

Different roads to discovery; Prontosil (hence sulfa drugs) and penicillin (hence beta-lactams).

Abstract

The important chemotherapeutic agents, Prontosil and pentenylpenicillin (penicillin F), were investigated initially by two men, Domagk and Fleming, who had been influenced by the horrendous wound infections of World War I. The very different pathways leading to their development and to that of the successor antibacterials (sulfa drugs, further penicillins, semi-synthetic penicillins), including the role played by patents, are discussed.

Entities: Chemical Species

Mesh：

Substances：

Year: 2009 PMID： 19283418 DOI： 10.1007/s10295-009-0553-8

Source DB: PubMed Journal: J Ind Microbiol Biotechnol ISSN： 1367-5435 Impact factor: 3.346

17 in total

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Journal: Biogr Mem Fellows R Soc Date: 1972

2. "Moldy Mary" and the Illinois Fruit and Vegetable Company.

Authors: M Scoutaris
Journal: Pharm Hist Date: 1996

3. Occurrence of penicillin-nucleus in culture broths.

Authors: K KATO
Journal: J Antibiot (Tokyo) Date: 1953-07 Impact factor: 2.649

4. Penicillin: I. Methods of assay.

Authors: W H Schmidt; A J Moyer
Journal: J Bacteriol Date: 1944-02 Impact factor: 3.490

5. Studies in the biochemistry of micro-organisms: The formation from glucose by members of the Penicillium chrysogenum series of a pigment, an alkali-soluble protein and penicillin-the antibacterial substance of Fleming.

Authors: P W Clutterbuck; R Lovell; H Raistrick
Journal: Biochem J Date: 1932 Impact factor: 3.857

6. Synthetic Penicillin.

Authors: V du Vigneaud; F H Carpenter; R W Holley; A H Livermore; J R Rachele
Journal: Science Date: 1946-11-08 Impact factor: 47.728

Review 7. A ferment of fermentations: reflections on the production of commodity chemicals using microorganisms.

Authors: Ronald Bentley; Joan W Bennett
Journal: Adv Appl Microbiol Date: 2008 Impact factor: 5.086

8. Classics in infectious diseases: on the antibacterial action of cultures of a penicillium, with special reference to their use in the isolation of B. influenzae by Alexander Fleming, Reprinted from the British Journal of Experimental Pathology 10:226-236, 1929.

Authors: A Fleming
Journal: Rev Infect Dis Date: 1980 Jan-Feb

9. Biosynthesis of penicillins; biological precursors for benzylpenicillin (penicillin G).

Authors: O K BEHRENS; J CORSE
Journal: J Biol Chem Date: 1948-09 Impact factor: 5.157

10. C.G. Paine and the earliest surviving clinical records of penicillin therapy.

Authors: M Wainwright; H T Swan
Journal: Med Hist Date: 1986-01 Impact factor: 1.419

14 in total

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Authors: Tobias A M Gulder; Bradley S Moore
Journal: Angew Chem Int Ed Engl Date: 2010-12-03 Impact factor: 15.336

Review 2. Predictive validity in drug discovery: what it is, why it matters and how to improve it.

Authors: Jack W Scannell; James Bosley; John A Hickman; Gerard R Dawson; Hubert Truebel; Guilherme S Ferreira; Duncan Richards; J Mark Treherne
Journal: Nat Rev Drug Discov Date: 2022-10-04 Impact factor: 112.288

Review 3. Recent Developments to Cope the Antibacterial Resistance via β-Lactamase Inhibition.

Authors: Zafar Iqbal; Jian Sun; Haikang Yang; Jingwen Ji; Lili He; Lijuan Zhai; Jinbo Ji; Pengjuan Zhou; Dong Tang; Yangxiu Mu; Lin Wang; Zhixiang Yang
Journal: Molecules Date: 2022-06-14 Impact factor: 4.927

Review 4. An evolutionary perspective on the history of flap reconstruction in the upper extremity.

Authors: Frank Fang; Kevin C Chung
Journal: Hand Clin Date: 2014-02-24 Impact factor: 1.907

Review 5. Antimicrobial and Antibiofilm Peptides.

Authors: Angela Di Somma; Antonio Moretta; Carolina Canè; Arianna Cirillo; Angela Duilio
Journal: Biomolecules Date: 2020-04-23

6. Ovicidal and Insecticidal Activities of Pyriproxyfen Derivatives with an Oxime Ester Group.

Authors: Guo-Shao Sun; Xin Xu; Shu-Hui Jin; Le Lin; Jian-Jun Zhang
Journal: Molecules Date: 2017-06-08 Impact factor: 4.411

7. Diversity and Antimicrobial Activity of Culturable Fungal Endophytes in Solanum mauritianum.

Authors: Sharon Pelo; Vuyo Mavumengwana; Ezekiel Green
Journal: Int J Environ Res Public Health Date: 2020-01-09 Impact factor: 3.390

8. Additions to N-Sulfinylamines as an Approach for the Metal-free Synthesis of Sulfonimidamides: O-Benzotriazolyl Sulfonimidates as Activated Intermediates.

Authors: Maximilian Bremerich; Christian M Conrads; Tim Langletz; Carsten Bolm
Journal: Angew Chem Int Ed Engl Date: 2019-11-11 Impact factor: 15.336

Review 9. Activation and Delivery of Tetrazine-Responsive Bioorthogonal Prodrugs.

Authors: Yayue Wang; Chang Zhang; Haoxing Wu; Ping Feng
Journal: Molecules Date: 2020-11-30 Impact factor: 4.411

Review 10. Immunotherapy and vaccination against infectious diseases.

Authors: Meinolf Ebbers; Christoph J Hemmer; Brigitte Müller-Hilke; Emil C Reisinger
Journal: Wien Klin Wochenschr Date: 2020-12-16 Impact factor: 1.704