BACKGROUND: To determine whether the cellular inflammatory marker of activated macrophages and monocytes, neopterin (NEO), and the acute-phase inflammatory markers sialic acid (SA) and C-reactive protein (CRP) are elevated in pregnancy and further elevated in the pregnancy syndrome preeclampsia. METHODS: Maternal plasma concentrations of NEO, SA, and CRP were measured by high-sensitivity enzyme-linked immunosorbent assay (ELISA) or high-performance liquid chromatography in 20 nonpregnant women, 40 women with uncomplicated pregnancies, 50 women with transient hypertension of pregnancy alone, 49 women with small for gestational age (SGA) infants without preeclampsia, and 47 women with preeclampsia. RESULTS: The mean concentration of plasma NEO, SA, and CRP were all significantly elevated in all groups of pregnant women compared to nonpregnant women (P < 0.001 for all). In addition, maternal plasma NEO concentrations were further elevated in women with preeclampsia compared to the other groups of pregnant women (P < 0.01). As expected, the acute-phase inflammatory markers CRP and SA correlated positively with each other. However, CRP was also correlated with the activated macrophage and monocyte marker NEO in women with transient hypertension of pregnancy and with preeclampsia (P < 0.05). CONCLUSIONS: The inflammatory markers NEO, SA, and CRP are all elevated during pregnancy. However, only NEO, a marker of macrophage and monocyte activation, was further elevated in women with preeclampsia. These data suggest that there is a striking increase in inflammation during pregnancy, and cellular immune activation is further elevated during preeclampsia.
BACKGROUND: To determine whether the cellular inflammatory marker of activated macrophages and monocytes, neopterin (NEO), and the acute-phase inflammatory markers sialic acid (SA) and C-reactive protein (CRP) are elevated in pregnancy and further elevated in the pregnancy syndrome preeclampsia. METHODS: Maternal plasma concentrations of NEO, SA, and CRP were measured by high-sensitivity enzyme-linked immunosorbent assay (ELISA) or high-performance liquid chromatography in 20 nonpregnant women, 40 women with uncomplicated pregnancies, 50 women with transient hypertension of pregnancy alone, 49 women with small for gestational age (SGA) infants without preeclampsia, and 47 women with preeclampsia. RESULTS: The mean concentration of plasma NEO, SA, and CRP were all significantly elevated in all groups of pregnant women compared to nonpregnant women (P < 0.001 for all). In addition, maternal plasma NEO concentrations were further elevated in women with preeclampsia compared to the other groups of pregnant women (P < 0.01). As expected, the acute-phase inflammatory markers CRP and SA correlated positively with each other. However, CRP was also correlated with the activated macrophage and monocyte marker NEO in women with transient hypertension of pregnancy and with preeclampsia (P < 0.05). CONCLUSIONS: The inflammatory markers NEO, SA, and CRP are all elevated during pregnancy. However, only NEO, a marker of macrophage and monocyte activation, was further elevated in women with preeclampsia. These data suggest that there is a striking increase in inflammation during pregnancy, and cellular immune activation is further elevated during preeclampsia.
Authors: Ronald G García; Johanna Celedón; Jesús Sierra-Laguado; Miguel A Alarcón; Carlos Luengas; Federico Silva; Mario Arenas-Mantilla; Patricio López-Jaramillo Journal: Am J Hypertens Date: 2007-01 Impact factor: 2.689
Authors: Richard J Levine; Cong Qian; Erik S Leshane; Kai F Yu; Lucinda J England; Enrique F Schisterman; Tuangsit Wataganara; Roberto Romero; Diana W Bianchi Journal: Am J Obstet Gynecol Date: 2004-03 Impact factor: 8.661
Authors: Catherine M Brown; Stephen T Turner; Kent R Bailey; Thomas H Mosley; Sharon L R Kardia; Heather J Wiste; Iftikhar J Kullo; Vesna D Garovic Journal: J Hypertens Date: 2013-11 Impact factor: 4.844
Authors: Houli Jiang; John C McGiff; Cristiano Fava; Gabriella Amen; Elisa Nesta; Giovanni Zanconato; John Quilley; Pietro Minuz Journal: Am J Hypertens Date: 2012-12-28 Impact factor: 2.689
Authors: Zuguo Mei; Hongtian Li; Mary K Serdula; Rafael C Flores-Ayala; Linlin Wang; Jian-Meng Liu; Laurence M Grummer-Strawn Journal: Am J Hum Biol Date: 2016-02-11 Impact factor: 2.947
Authors: Edith H van den Hooven; Yvonne de Kluizenaar; Frank H Pierik; Albert Hofman; Sjoerd W van Ratingen; Peter Y J Zandveld; Jan Lindemans; Henk Russcher; Eric A P Steegers; Henk M E Miedema; Vincent W V Jaddoe Journal: Environ Health Perspect Date: 2012-02-03 Impact factor: 9.031