| Literature DB >> 19280165 |
L Kowalzick1, L Eickenscheidt, M Komar, E Schaarschmidt.
Abstract
A 51-year-old white man developed de novo a cutaneous malignant melanoma (Stage Ia) after a 30-month treatment period with TNF-alpha-antagonists, consecutively using infliximab, adalimumab and etanercept because of a recalcitrant moderate to severe plaque psoriasis. The patient previously had been treated fumarates for 4 years, cyclosporine A for 2 months and methotrexate for 5 weeks. He also received cycles of cream PUVA and UVB before and then between systemic medications. A possible causal connection between development of melanoma and immunosuppressive treatment is discussed in the light of recent literature. The termination of TNF-alpha-antagonist therapy following development of melanoma is recommended.Entities:
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Year: 2009 PMID: 19280165 DOI: 10.1007/s00105-008-1695-8
Source DB: PubMed Journal: Hautarzt ISSN: 0017-8470 Impact factor: 0.751