Literature DB >> 19277476

Secretory expression of K88 (F4) fimbrial adhesin FaeG by recombinant Lactococcus lactis for oral vaccination and its protective immune response in mice.

Chun Xia Hu1, Zi Rong Xu, Wei Fen Li, Dong Niu, Niu Dong, Ping Lu, Ling Lin Fu.   

Abstract

K88 (F4) fimbrial adhesin, FaeG, was expressed extracellularly in Lactococcus lactis using a nisin-controlled gene expression system. The antibody response and protective efficacy of the recombinant bacteria (L. lactis [spNZ8048-faeG]) against live enterotoxigenic E. coli (ETEC) C(83549) challenge were evaluated in ICR mice. Mice vaccinated with L. lactis [spNZ8048-faeG] had a significantly increased antigen-specific IgG level in the serum and decreased mortality rate (P < 0.05) compared with the control. This indicates that oral immunization of L. lactis [spNZ8048-faeG] can induce an immune-response protection upon challenge with live ETEC in ICR mice.

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Year:  2009        PMID： 19277476     DOI： 10.1007/s10529-009-9966-8

Source DB:  PubMed          Journal:  Biotechnol Lett        ISSN： 0141-5492            Impact factor:   2.461


  5 in total

1.  Immune responses elicited in mice with recombinant Lactococcus lactis expressing F4 fimbrial adhesin FaeG by oral immunization.

Authors:  Shujie Liu; Yongming Li; Ziwei Xu; Yicheng Wang
Journal:  Vet Res Commun       Date:  2010-06-09       Impact factor: 2.459

2.  Effect of active immunization against a recombinant mouse granulocyte-macrophage colony-stimulating factor/somatostatin fusion protein on the growth of mice.

Authors:  Bingbing Wu; Ruili Qi; Bin Li; Taoyan Yuan; Heshan Liu; Jun He; Zhiwei Lin; Weifen Li; Yan Fu; Dong Niu
Journal:  Mol Biol Rep       Date:  2012-02-04       Impact factor: 2.316

3.  Identification of fibrinogen-binding proteins of Aspergillus fumigatus using proteomic approach.

Authors:  Santosh Kumar Upadhyay; Poonam Gautam; Hrishikesh Pandit; Yogendra Singh; Seemi Farhat Basir; Taruna Madan
Journal:  Mycopathologia       Date:  2011-08-26       Impact factor: 2.574

4.  Cloning and Expression of Genes Encoding F107-C and K88-1NT Fimbrial Proteins of Enterotoxigenic Escherichia coli from Piglets.

Authors:  Nguyen Hoang Loc; Le My Tieu Ngoc; Tran Thuy Lan; Le Quoc Viet; Le Duc Thao; Hoang Tan Quang; Dinh Thi Bich Lan; Phung Thang Long
Journal:  Indian J Microbiol       Date:  2013-03-16       Impact factor: 2.461

Review 5.  Development of vaccine delivery vehicles based on lactic acid bacteria.

Authors:  Shirin Tarahomjoo
Journal:  Mol Biotechnol       Date:  2012-06       Impact factor: 2.695
  5 in total

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