PURPOSE: DNA damage recognition and repair play a major role in risk for breast cancer. We investigated 104 single nucleotide polymorphisms (SNP) in 17 genes whose protein products are involved in double-stranded break repair (DSBR). EXPERIMENTAL DESIGN: We used a case-control design. Both the case individuals affected with breast cancer or with both breast and ovarian cancers and the controls had similar familial risk of breast cancer and were participants in a high-risk cancer registry. RESULTS: We found that 12 of the polymorphisms are associated with breast or breast and ovarian cancers, most notably rs16888927, rs16888997, and rs16889040, found in introns of RAD21, suggesting that SNPs in other genes in the DSBR pathway in addition to BRCA1 and BRCA2 may affect breast cancer risk. CONCLUSIONS: SNPs within or near several DSBR DNA repair pathway genes are associated with breast cancer in individuals from a high-risk population. In addition, our study reemphasizes the unique perspective that recruitment of cases and controls from family cancer registries has for gene discovery studies.
PURPOSE: DNA damage recognition and repair play a major role in risk for breast cancer. We investigated 104 single nucleotide polymorphisms (SNP) in 17 genes whose protein products are involved in double-stranded break repair (DSBR). EXPERIMENTAL DESIGN: We used a case-control design. Both the case individuals affected with breast cancer or with both breast and ovarian cancers and the controls had similar familial risk of breast cancer and were participants in a high-risk cancer registry. RESULTS: We found that 12 of the polymorphisms are associated with breast or breast and ovarian cancers, most notably rs16888927, rs16888997, and rs16889040, found in introns of RAD21, suggesting that SNPs in other genes in the DSBR pathway in addition to BRCA1 and BRCA2 may affect breast cancer risk. CONCLUSIONS: SNPs within or near several DSBR DNA repair pathway genes are associated with breast cancer in individuals from a high-risk population. In addition, our study reemphasizes the unique perspective that recruitment of cases and controls from family cancer registries has for gene discovery studies.
Authors: Bettina Kuschel; Annika Auranen; Simon McBride; Karen L Novik; Antonis Antoniou; Julian M Lipscombe; Nicholas E Day; Douglas F Easton; Bruce A J Ponder; Paul D P Pharoah; Alison Dunning Journal: Hum Mol Genet Date: 2002-06-01 Impact factor: 6.150
Authors: J M Satagopan; K Offit; W Foulkes; M E Robson; S Wacholder; C M Eng; S E Karp; C B Begg Journal: Cancer Epidemiol Biomarkers Prev Date: 2001-05 Impact factor: 4.254
Authors: Bert Gold; Tomas Kirchhoff; Stefan Stefanov; James Lautenberger; Agnes Viale; Judy Garber; Eitan Friedman; Steven Narod; Adam B Olshen; Peter Gregersen; Kristi Kosarin; Adam Olsh; Julie Bergeron; Nathan A Ellis; Robert J Klein; Andrew G Clark; Larry Norton; Michael Dean; Jeff Boyd; Kenneth Offit Journal: Proc Natl Acad Sci U S A Date: 2008-03-07 Impact factor: 11.205
Authors: Maria A Loizidou; Thalia Michael; Susan L Neuhausen; Robert F Newbold; Yiola Marcou; Eleni Kakouri; Maria Daniel; Panayiotis Papadopoulos; Simos Malas; Andreas Hadjisavvas; Kyriacos Kyriacou Journal: Breast Cancer Res Treat Date: 2008-06-16 Impact factor: 4.872
Authors: E Levy-Lahad; A Lahad; S Eisenberg; E Dagan; T Paperna; L Kasinetz; R Catane; B Kaufman; U Beller; P Renbaum; R Gershoni-Baruch Journal: Proc Natl Acad Sci U S A Date: 2001-03-13 Impact factor: 11.205
Authors: E J Duell; R C Millikan; G S Pittman; S Winkel; R M Lunn; C K Tse; A Eaton; H W Mohrenweiser; B Newman; D A Bell Journal: Cancer Epidemiol Biomarkers Prev Date: 2001-03 Impact factor: 4.254
Authors: Luisel J Ricks-Santi; Jing Nie; Catalin Marian; Heather M Ochs-Balcom; Maurizio Trevisan; Stephen B Edge; Yasmine Kanaan; Jo L Freudenheim; Peter G Shields Journal: Genet Epidemiol Date: 2013-05-14 Impact factor: 2.135
Authors: Hui-Chen Wu; Lissette Delgado-Cruzata; Nicola Machella; Qiao Wang; Regina M Santella; Mary Beth Terry Journal: Cancer Causes Control Date: 2013-09-24 Impact factor: 2.506
Authors: Aya Masaoka; Natalie R Gassman; Julie K Horton; Padmini S Kedar; Kristine L Witt; Cheryl A Hobbs; Grace E Kissling; Keizo Tano; Kenjiro Asagoshi; Samuel H Wilson Journal: PLoS One Date: 2013-06-27 Impact factor: 3.240
Authors: Yadav Sapkota; Paula Robson; Raymond Lai; Carol E Cass; John R Mackey; Sambasivarao Damaraju Journal: Eur J Hum Genet Date: 2012-01-18 Impact factor: 4.246